[1]许思思,陈悦#.豚鼠形觉剥夺性近视视网膜组织中褪黑素受体表达及眼压的变化[J].郑州大学学报(医学版),2009,(03):636-637.
　XU Sisi,CHEN Yue.Expression of melatonin receptar and change of intraocular pressure in form deprived myopia in guinea pigs[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):636-637.
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豚鼠形觉剥夺性近视视网膜组织中褪黑素受体表达及眼压的变化 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
636-637
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expression of melatonin receptar and change of intraocular pressure in form deprived myopia in guinea pigs
作者:
许思思; 陈悦#
郑州大学第一附属医院眼科郑州450052
Author(s):
XU Sisi; CHEN Yue
Department of Ophthalmology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
豚鼠; 形觉剥夺性近视; 眼压; 褪黑素受体
Keywords:
guinea pig; form deprived myopia; intraocular pressure; melatonin receptor
分类号:
R778.1
摘要:
研究豚鼠形觉剥夺性近视视网膜组织中褪黑素受体MT1的表达，探讨其与眼压变化的关系。方法：将出生5~7 d 20只的豚鼠单眼半透明眼罩遮盖，遮盖眼为实验眼，未遮盖眼为对照眼。实验前及遮盖8周后行带状光检影镜测眼屈光度数， A超测量眼轴长度,确认豚鼠形觉剥夺性近视模型制造成功。于遮盖8周后测量实验组和对照组眼压，并应用免疫组织化学染色方法检测视网膜中褪黑素受体亚型MT1的表达水平。结果：形觉剥夺8周后实验眼眼压（2.51±0.10） kPa较对照眼(1.97±0.08) kPa升高(P＜0.05），豚鼠形觉剥夺性近视视网膜褪黑素受体免疫反应阳性细胞数目减少（P＜0.05）。结论：褪黑素可能影响眼压的调节，与形觉剥夺性近视的形成密切有关。
Abstract:
To investigate the expression of melatonin recepter MT1 of retina and the change of intraocular pressure in form deprived myopia(FDM) in guinea pig.Methods:20 Guinea pigs 5~7 dayold were worn with monocular translucent goggles for 8 weeks.The form deprived eyes were taken for the experimental eyes,others were taken for the contral eyes.Before and after experement,refractive status was measured by ribbon shape lighting skiascope,and axial length was measured by ultrasound A.In this way,we made sure the model of FDM in guinea pig was made successfully

参考文献/References:

［1］Rada JA，Wiechmann AF.Melatonin Receptors in chick ocular tissues:implications for a role of melatonin in ocular growth regulation［J］.Invest Ophthalmol and Vis Sci,2006,47(1)：25
[2]AlarmaEstrany P,Pintor J.Melatonin receptors in the eye:location, second messengers and role in ocular physiology［J］.Pharmacol Ther,2007,113(3):507
[3]曹亚菲,吕勇,闫磐石.豚鼠形觉剥夺性近视模型眼压昼夜节律的改变［J］.医药论坛杂志，2007,29(4):36
[4]Wallman J,Adams JI.Developmental aspects of experimental myopia in chicks:susceptibility,recovery and relation to emmetropization［J］.Vision Res,1987,27:1 139
[5]胡文政，褚仁远，张利能.豚鼠实验性近视眼巩膜的羟脯氨酸含量改变［J］.眼视光学杂志，2001，3：103
[6]李晓艳，张卯年.褪黑素的抗氧化作用及其在眼部疾病应用的研究进展［J］.国际眼科杂志，2008，8（8）：1 657

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备注/Memo

备注/Memo:
#通讯作者，女，1964年生，博士，主任医师，研究方向：眼屈光与眼外伤,Email：chenyue@zzu.edu.cn
更新日期/Last Update: 2010-05-28