[1]刘 灿,陈丹杰,余军林,等.晚期食管鳞癌患者血清sPD-L1与组织PD-L1的表达及与预后的关系[J].郑州大学学报(医学版),2019,(04):500-503.[doi:10.13705/j.issn.1671-6825.2018.12.039]
　LIU Can,CHEN Danjie,YU Junlin,et al.Detection of serum sPD-L1 and tissue PD-L1 in patients with advanced esophageal squamous cell carcinoma and prognostic value[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(04):500-503.[doi:10.13705/j.issn.1671-6825.2018.12.039]
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晚期食管鳞癌患者血清sPD-L1与组织PD-L1的表达及与预后的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年04期
页码:
500-503
栏目:
食管癌研究
出版日期:
2019-07-20

文章信息/Info

Title:
Detection of serum sPD-L1 and tissue PD-L1 in patients with advanced esophageal squamous cell carcinoma and prognostic value
作者:
刘 灿; 陈丹杰; 余军林; 孟祥瑞; 辛 道; 刘德恩; 王 峰
郑州大学第一附属医院肿瘤科 郑州 450052
Author(s):
LIU Can; CHEN Danjie; YU Junlin; MENG Xiangrui; XIN Dao; LIU De'en; WANG Feng
Department of Oncology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
食管鳞癌;  程序性死亡配体1;  预后
Keywords:
esophageal squamous cell carcinoma;  programmed cell death ligand 1;  prognosis
分类号:
R735.1
DOI:
10.13705/j.issn.1671-6825.2018.12.039
摘要:
目的:探讨血清可溶性程序性死亡配体1(sPD-L1)水平、组织PD-L1的表达对晚期食管鳞癌的预后判断价值。方法:收集晚期食管鳞癌患者127例,健康对照71名,ELISA法测定健康对照组及食管鳞癌组化疗前血清sPD-L1水平,同时检测炎性指标NLR、SII水平; 免疫组化法测定食管鳞癌组织中PD-L1的表达,分析血清sPD-L1与组织PD-L1及NLR、SII的关系; Kaplan-Meier法和Cox回归分析晚期食管鳞癌患者预后影响因素。结果:食管鳞癌组血清sPD-L1、NLR、SII水平均高于健康对照组(P均<0.05)。食管鳞癌患者血清sPD-L1水平与组织PD-L1表达无关(P=0.619),但与炎性指标NLR、SII有关(P均<0.05)。Kaplan-Meier法分析结果表明,sPD-L1水平、PD-L1表达和肿瘤部位与晚期食管鳞癌患者的预后有关(P均<0.05)。Cox回归分析表明sPD-L1与PD-L1是晚期食管鳞癌预后的独立影响因素,高sPD-L1水平、PD-L1阳性的患者死亡风险增加(HR=1.533,95%CI=1.063-2.211; HR=1.703,95%CI=1.058-2.739)。结论:血清sPD-L1与组织PD-L1可用于晚期食管鳞癌患者的预后判定。
Abstract:
Aim:To explore the prognostic value of serum soluble programmed cell death ligand 1(sPD-L1)and tissue PD-L1 expression in advanced esophageal squamous cell carcinoma(ESCC).Methods:A total of 127 patients with advanced ESCC and 71 healthy volunteers(control group)were collected.Serum sPD-L1 in the control group and ESCC group was measured by ELISA.Meanwhile, NLR and SII,the inflammatory indexes in the two groups were calculated.The expression of PD-L1 in ESCC tissue was detected by immunohistochemistry.The relationship between serum sPD-L1 and tissue PD-L1,NLR,SII was analyzed. Kaplan-Meier analysis and Cox regression analysis were used to determine the risk factors on the prognosis.Results:Serum sPD-L1,NLR and SII in ESCC group were higher than those in control group(P<0.05). The level of sPD-L1 in ESCC was not associated with the expression of PD-L1(P=0.619), but it was associated with NLR and SII(P<0.05). Kaplan-Meier analysis indicated that sPD-L1, PD-L1 and tumor sites were related to the prognosis of advanced ESCC(P<0.05). Cox regression analysis showed that sPD-L1 and PD-L1 were independent prognostic factors for advanced ESCC, and high sPD-L1 level or PD-L1 positive patients had a significant increased risk of death(HR=1.533,95%CI=1.063-2.211; HR=1.703,95%CI=1.058-2.739).Conclusion:Serum sPD-L1 level and tissue PD-L1 expression can be prognostic indicators for patients with advanced ESCC.

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备注/Memo

备注/Memo:
【作者简介】王峰,通信作者,男,1975年10月生,博士,副教授,研究方向:消化道肿瘤基础与临床,E-mail:fengw010@163.com
更新日期/Last Update: 2019-07-20