[1]钟志超,范洪领,尹金宝,等.氯通道电流在离体大鼠海马缺血缺氧性神经元凋亡中的变化及SITS的拮抗作用*[J].郑州大学学报(医学版),2011,(03):367.
 ZHONG Zhichao,FAN Hongling,YIN Jinbao,et al. Changes of chloride channel currents during cultured rat hippocampal neuronal apoptosis and antieffects of SITS[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(03):367.
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氯通道电流在离体大鼠海马缺血缺氧性神经元凋亡中的变化及SITS的拮抗作用*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年03期
页码:
367
栏目:
论著
出版日期:
2011-05-15

文章信息/Info

Title:
 Changes of chloride channel currents during cultured rat hippocampal neuronal apoptosis and antieffects of SITS
作者:
 钟志超范洪领尹金宝郑原印许黎娟常全忠#
 遵义医学院珠海校区生理学教研室 珠海 519041
Author(s):
 ZHONG ZhichaoFAN HonglingYIN JinbaoZHENG YuanyinXU LijuanCHANG Quanzhong
 Department of Physiology, Zhuhai Campus of Zunyi Medical College,Zhuhai 519041
关键词:
 氯通道NO脑缺血海马大鼠
分类号:
R966;R338.8
文献标志码:
A
摘要:
 目的:观察氯通道电流在NO诱导大鼠海马神经元损伤中的变化。方法:离体培养12 d的SD大鼠海马神经元,随机分为正常对照组、SIN1处理组和SIN1处理后加氯通道阻断剂SITS组,观察细胞凋亡情况,全细胞膜片钳技术记录神经元氯通道电流。结果:3组神经元凋亡率比较,差异有统计学意义(F=3.120,P=0.006)。NO处理后的神经元氯通道电流增加;SITS能部分抑制神经元损伤后氯通道电流的增加。结论:氯通道可能参与了NO诱导的离体海马神经元损伤。

参考文献/References:

 [1]Yuan J, Yankner BA. Apoptosis in the nervous system[J]. Nature,2000, 407(6805):802
[2]Gao TM, Pulsinelli WA, Xu ZC. Changes in membrane properties of CA1 pyramidal neurons after transient forebrain ischemia in vivo[J]. Neuroscience, 1999, 90(3):771
[3]Inoue H, Ohtaki H, Nakamachi T. Anion channel blockers attenuate delayed neuronal cell death induced by transient forebrain ischemia[J]. J Neurosci Res,2007, 85(7):1427
[4]Kawasaki M, Uchida S,Momkawa T,et al. Cloning and expression of a protein kinase Cregulated chloride channel abundantly expressed in rat brain neuronal cells[J]. Neuron,1994,12(3):597
[5]Li YH,Gong PL. Neuroprotective effect of dauricine in cortical neuron culture exposed to hypoxia and hypoglycemia: involvement of correcting perturbed calcium homeostasis[J].Can J Physiol Pharmacol,2007,85(6):621
[6]Small DL, Tauskela J, Xia ZL. Role for chloride but not potassium channels in apoptosis in primary rat cortical cultures[J]. Neurosci Lett,2002,334(2):95
[7]常全忠,张淑玲.雌激素对NMDA诱导离体大鼠海马神经元凋亡中的作用[J].中国药理学通报,2006,22(4):456

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备注/Memo

备注/Memo:
 *贵州省科技厅基金资助项目30125013,20093075;珠海市科技局基金资助项目PC20081010
#通讯作者,男,1965年12月生,博士,教授,研究方向:神经生物学,E-mail:cqzchang@tom.com
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