[1]常云丽),郑鹏远)#,郭涛),等.家族史阳性食管癌组织中hMSH2和PTEN蛋白的表达*[J].郑州大学学报(医学版),2009,(01):28-30.
 CHANG Yunli),ZHENG Pengyuan),GUO Tao),et al.Expression of hMSH2 and PTEN in esophageal cancer tissues from the esophageal cancer patients with and without family history[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):28-30.
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家族史阳性食管癌组织中hMSH2和PTEN蛋白的表达* ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
28-30
栏目:
食管癌研究
出版日期:
2009-01-01

文章信息/Info

Title:
Expression of hMSH2 and PTEN in esophageal cancer tissues from the esophageal cancer patients with and without family history
作者:
常云丽1)郑鹏远1)#郭涛2)常志伟2)任景丽2)李吉林3)范宗民2)
1)郑州大学第二附属医院消化内科郑州4500142)河南省食管癌重点开放实验室;郑州大学第一附属医院;郑州大学基础医学院郑州4500523)林州市姚村食管癌医院病理科林州4565924)获嘉县红十字会医院病理科获嘉4538005)新乡医学院癌症研究中心新乡453003
Author(s):
CHANG Yunli1)ZHENG Pengyuan1)GUO Tao2)CHANG Zhiwei2)REN Jingli2)LI Jilin3)etc
关键词:
食管肿瘤家族史遗传易感性hMSH2PTEN
Keywords:
esophageal cancer family history genetic susceptibility hMSH2 PTEN
分类号:
R735.1
摘要:
探讨家族史阳性和阴性食管癌患者癌组织中hMSH2和PTEN蛋白的表达变化与食管癌遗传易感性的关系。方法:采用免疫组化ABC法检测河南省食管癌高发区64例食管癌患者(家族史阳性31例)手术切除标本癌组织、癌旁组织中hMSH2和PTEN蛋白表达情况。结果:家族史阳性食管癌患者hMSH2蛋白阳性表达率为55%(17/31),低于家族史阴性患者的82%(27/33)(P<0.05)。家族史阳性和阴性患者PTEN蛋白阳性表达率分别为42%(13/31)和21%(7/33),差异无统计学意义(P>0.05)。结论:hMSH2表达异常与食管癌高易感性密切相关,而PTEN蛋白表达与食管癌遗传易感性无相关性。
Abstract:
To study the changes of hMSH2 and PTEN expression in esophageal cancer(EC) patients with and without family history.Methods:The immunohistochemical method (ABC) was used to detect the expression of hMSH2 and PTEN protein in 64 cases of EC specimens (31 cases with FH+).Results: The positive expression of hMSH2 was significantly lower in the patients with FH+ than that in patients with FH-(55% vs 82%,P<0.05).The positive expression of PTEN in the patients with FH+ was 42%(13/31),which didn't differ from 21%(7/33) in the patients with FH-(P>0.05).Conclusion: Abnormal expression of hMSH2,not PTEN, is related with high esophageal cancer susceptibility, of PTEN esophageal carcinogenesis.

参考文献/References:

[1]Hu N, Dawsey SM, Wu M,et al. Familial aggregation of oesophageal cancer in Yangcheng Country, Shanxi Province, China[J]. Int J Epidemiol, 1992, 21(5): 877
[2]Chlappini F, GrossGoupil M, Saffroy R, et al. Microsatellite instability mutator phenotype in hepatocellular carcinoma in nonalcoholic and nonvirally infected normal livers [J]. Carcinogenesis, 2004, 25(4): 541
[3]Arch EM, Goodman BK, Van Wesep RA, et al. Deletion of PTEN in a patient with Bannayan Riley Ruvalcaba syndrom suggests allelism with Cowden diease[J]. Am J Med Genet, 1997,71(4):489
[4]王立东,樊慧,焦新英,等. 河南食管癌高发区95对单卵双胞胎疾病谱和2323例食管癌患者家族史调查[J]. 中华肿瘤防治杂志,2006,10(13):1 521
[5]许良中,杨文涛. 免疫组织化学反应结果的判断[J]. 中国癌症杂志,1996,6(4):229
[6]Coleman MG, Gough AC, Bunyan DJ, et al. Minisatellite instability is found in colorectal tumors with mismatch repair deficiency[J].Br J Cancer,2001,85(10):1 486
[7]Haier J, Nicolson GL. PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow[J]. Oncogene, 2002, 21(9):1450
[8]Mutter GL, Lin MC, Fitzgerald JT, et al. Changes in endometrial PTEN expression throughout the human menstrual cycle[J].J Clin Endocrinol Metab, 2000, 85(6): 2 334

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备注/Memo

备注/Memo:
*国家杰出青年科学基金资助项目30025016;国家自然科学基金资助项目30670956;河南省医学创新人才工程资助项目200084 #通讯作者,郑鹏远,男,1965年生,博士,教授,研究方向:消化系统疾病,Email:medp7123@yahoo.com #通讯作者,王立东,男,1958年生,博士,教授,研究方向:食管和贲门癌变机制和防治研究,Email:ldwang@zzu.edu.cn
更新日期/Last Update: 2010-05-18