[1]张广平)),王立东)﹟,冯常炜),等.食管癌高发区同卵双胞胎食管、贲门和胃窦活检组织病理比较*[J].郑州大学学报(医学版),2009,(01):39-41.
 ZHANG Guangping),WANG Lidong),FENG Changwei),et al.Histopathological comparison on the biopsies at esophagus, gastric cardia and antrum from monozygotic twins at highincidence area for esophageal cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):39-41.
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食管癌高发区同卵双胞胎食管、贲门和胃窦活检组织病理比较*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
39-41
栏目:
食管癌研究
出版日期:
2009-01-01

文章信息/Info

Title:
Histopathological comparison on the biopsies at esophagus, gastric cardia and antrum from monozygotic twins at highincidence area for esophageal cancer
作者:
张广平1)2)王立东1)冯常炜3)樊慧1)李吉林4)张延瑞5)王晗晶1)高社干2)郭涛1)
1)河南省食管癌重点开放实验室;郑州大学第一附属医院;郑州大学基础医学院郑州4500522)河南科技大学第一附属医院肿瘤科;河南科技大学肿瘤研究所洛阳4710033)郑州大学第二附属医院消化内科郑州4500034)林州市姚村食管癌医院病理科林州4565925)河南省人民医院消化内科郑州4500036)濮阳市人民医院肿瘤内科濮阳4570007)林州市中心医院胸外科林州456550
Author(s):
ZHANG Guangping12)WANG Lidong1)FENG Changwei3)FAN Hui1)LI Jilin4)ZHANG Yanrui5)etc
关键词:
同卵双胞胎食管肿瘤贲门肿瘤癌前病变病理学
Keywords:
monozygotic twins esophageal cancer gastric cardia cancer precancerous lesion
分类号:
R735.1
摘要:
比较分析河南省食管癌高发区同卵双胞胎成员食管、贲门和胃窦黏膜活检组织病理结果,探讨遗传和环境因素对食管和贲门癌变的影响。方法:对108对来自于河南省食管癌高发区的同卵双胞胎进行问卷调查,对其中22对自愿接受胃镜检查者进行黏膜活检组织病理学检查。结果:①108对同卵双胞胎中,共发现癌症13例,其中食管癌7例(均为男性,单发),食管癌发生率0.065%(7/108)。②接受胃镜检查的22对双胞胎中4例食管癌患者,1例胃癌患者,癌前病变3例,均为单发;18对未患癌患者中,3对慢性轻度食管炎和1对慢性浅表性胃炎为双发,其余14对所患疾病均为单发。结论:环境因素对食管癌变的影响远大于遗传因素。
Abstract:
To determine the impact of genetic and environment factors on esophageal and gastric cardia carcinogenesis by comparing the alternations of esophageal and gastric cardia precancerous lesions of monozygotic twins.Methods:Questionnaire (n=108 pairs) endoscopy biopsy and histopathological examination (n=22 pairs) were applied.Results:Of the 108 pairs of monozygotic twins from the highincidence area for esophageal cancer (EC) in Henan province,7(0.065%) male cases were identified with EC (occurred only in one member of the twins).Of the 22 monozygotic twins examined with endoscopy and biopsy,there were 4 cases with EC(occured only in one member of the twin),1 case with gastric adenocarcinoma,3 cases with esophageal precancerous lesions;of the 18 noncancer twins, different epithelial lesions were identified in 14 pairs of twins and only in one member of the twin,excepting for 3 pairs of chronie supor filial gastritis and 1 pair of chronic mild esophagitis.Conclusion:Environmental factors may play a major role in esophageal carcinogenesis.

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备注/Memo

备注/Memo:
#通讯作者,男,1958年生,博士,教授,研究方向:食管和贲门癌变机制和防治研究,Email:ldwang@zzu.edu.cn *国家科技部863重大资助项目2006AA02A403;973计划前期研究专项资助项目2007CB516812
更新日期/Last Update: 2010-05-18