[1]叶柯)△,葛红),蒋月),等.放疗前后食管鳞状细胞癌组织中P53和Caspase3蛋白的表达*[J].郑州大学学报(医学版),2009,(01):45-47.
 YE Ke),GE Hong),JIANG Yue),et al.Expression of P53 and Caspase3 in esophageal squamous cell carcinoma tissue before and after radiotherapy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):45-47.
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放疗前后食管鳞状细胞癌组织中P53和Caspase3蛋白的表达*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
45-47
栏目:
食管癌研究
出版日期:
2009-01-01

文章信息/Info

Title:
Expression of P53 and Caspase3 in esophageal squamous cell carcinoma tissue before and after radiotherapy
作者:
叶柯1)葛红1)蒋月1)刘海龙1)马杰2)
1)河南省肿瘤医院放疗科郑州4500082)河南省肿瘤医院病理科郑州450008
Author(s):
YE Ke1) GE Hong1)JIANG Yue1) LIU Hailong1) MA Jie2)
1)Department of Radiation Oncology, Henan Tumor Hospital, Zhengzhou 4500082)Department of Pathology, Henan Tumor Hospital, Zhengzhou 450008
关键词:
食管肿瘤鳞状细胞癌P53Caspase3放疗敏感性
Keywords:
esophageal neoplasmsquamous cell carcinomaP53Caspase3radiosensitivity
分类号:
R735.1
摘要:
检测放疗前后食管鳞状细胞癌组织中P53和Caspase3蛋白的表达,探讨2者与放疗敏感性的关系。方法:采用免疫组织化学SP法检测56例食管鳞状细胞癌放疗前胃镜活检标本及放疗后食管癌根治性切除术后标本P53和Caspase3蛋白的表达水平,分析2者放疗前后表达的差异及其与放疗后病理反应分级的关系。结果:放疗前后标本中P53蛋白的表达水平分别为0.30±0.18、0.27±0.14,2者相比,差异无统计学意义(P>0.05);放疗前后标本中Caspase3蛋白的表达水平分别为0.33±0.18、0.43±0.27,2者相比,差异有统计学意义(P<0.05)。放疗前Caspase3蛋白的表达与放疗后病理反应程度有关(P<0.05)。结论:Caspase3的表达可作为中晚期食管鳞状细胞癌术前放疗的筛选指标之一。
Abstract:
To detect the expression levels of P53 and Caspase3 before and after radiotherapy in esophageal squamous cell carcinoma (ESCC) tissue.Methods:The expression levels of P53 and Caspase3 in samples from 56 patients with ESCC before and after radiotherapy were detected with SP immunohistochemistry method.Results: The expression level of P53 in samples before and after radiotherapy were 0.30±0.18 and 0.27±0.14, and those for Caspase3 were 0.33±0.18 and 0.43±0.27, respectively.There was statistical difference in the expression level of Caspase3 before and after radiotherapy. The expression of Caspase3 before radiotherapy was related with pathologic tumor response to preoperative radiotherapy(P<0.05).Conclusion: Caspase3 before radiotherapy can be considered as a screening index for preoperative radiotherapy.

参考文献/References:

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备注/Memo

备注/Memo:
*河南省科技攻关基金资助项目(2005) △女,1975年生,硕士,主治医师,研究方向:肿瘤放射治疗学
更新日期/Last Update: 2010-05-18