[1]贺德志△,李建生#,梁倩萍.食管鳞状细胞癌组织中Claudin7和Ecadherin蛋白的表达[J].郑州大学学报(医学版),2009,(01):59-52.
 HE Dezhi,LI Jiansheng,LIANG Qianping.Expression of Claudin7 and Ecadherin in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):59-52.
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食管鳞状细胞癌组织中Claudin7和Ecadherin蛋白的表达 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
59-52
栏目:
食管癌研究
出版日期:
2009-01-01

文章信息/Info

Title:
Expression of Claudin7 and Ecadherin in esophageal squamous cell carcinoma tissue
作者:
贺德志李建生#梁倩萍
郑州大学第一附属医院消化内科;河南省高等学校临床医学重点学科开放实验室郑州450052
Author(s):
HE DezhiLI JianshengLIANG Qianping
Department of Gastroenterology, the First Affiliated Hospital,Zhengzhou University;KeyDisciplines Laboratory ClinicalMedicine Henan,Zhengzhou 450052
关键词:
食管肿瘤鳞状细胞癌Claudin7Ecadherin
Keywords:
esophageal neoplasmsquamous cell carcinomaClaudin7Ecadherin
分类号:
R735.1
摘要:
研究食管鳞状细胞癌组织中Claudin7和Ecadherin的表达及其与食管癌生物学行为的关系。方法:采用免疫组织化学SP法检测72例食管鳞状细胞癌术后标本中Claudin7和Ecadherin的表达,并分析二者与食管鳞状细胞癌患者临床病理特征的关系。结果:食管鳞状细胞癌组织中Claudin7的异常表达率为72%(52/72),其与食管鳞状细胞癌的分化程度、浸润深度、TNM分期和淋巴结转移有关(P均<0.05)。食管鳞状细胞癌组织中Ecadherin的异常表达率为66.7%(48/72),其与食管鳞状细胞癌的分化程度、浸润深度、TNM分期、淋巴结转移和静脉侵犯有关(P均<0.05)。Claudin7和Ecadherin的表达呈正相关(rs=0.735,P=0.001)。结论:食管鳞状细胞癌组织中Claudin7和Ecadherin的表达与食管癌的发生发展、侵袭转移和预后密切相关,两指标的联合检测对食管鳞状细胞癌的治疗和预后的判断有指导作用。
Abstract:
To investigate the relationship between the expression of Claudin7, Ecadherin proteins and clinicopathologic parameter in ESCC.Methods:Immunohistochemical SP method was used to detect the expression of Claudin7 and Ecadherin proteins in ESCC.Results: The ratio of abnormal Claudin7 expression was 72%(52/72) in ESCC.Abnormal expression of Claudin7 was correlated with histological grade, clinical stage, lymph node metastasis and infiltration depth in ESCC.The ratio of abnormal expression of Ecadherin was 66.7%(48/72) in ESCC. Abnormal expression of Ecadherin was associated with histological grade,clinical stage, lymph node metastasis,infiltration depth and venous invasion in ESCC. Abnormal Claudin7 expression was associated with reduced Ecadherin expression in ESCC(rs=0.735,P=0.001).Conclusion: The expressions of Claudin7 and Ecadherin correlate with the development, invasion, metastasis and prognosis of ESCC. Simultaneous detection expression of Claudin7 and Ecadherin may be useful for the prediction of treatment and prognosis in ESCC.

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备注/Memo

备注/Memo:
△男,1974年生,硕士,主治医师,研究方向:消化道肿瘤,Email:hedezhi@zzu.edu.cn #通讯作者,男,1955年生,博士,教授,主任医师,研究方向:消化道肿瘤,Email:lijiansheng@medmail.com.cn
更新日期/Last Update: 2010-05-18