[1]乔军波)△,张谢夫)#,李珊珊),等.胃癌组织中层黏连蛋白受体67LR和半乳糖凝集素3蛋白的表达[J].郑州大学学报(医学版),2009,(01):102-105.
 QIAO Junbo),ZHANG Xiefu),LI Shanshan),et al.Expression of 67LR and Galectin3 in the patients with gastric carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):102-105.
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胃癌组织中层黏连蛋白受体67LR和半乳糖凝集素3蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
102-105
栏目:
论著
出版日期:
2009-01-01

文章信息/Info

Title:
Expression of 67LR and Galectin3 in the patients with gastric carcinoma
作者:
乔军波1)张谢夫1)#李珊珊2)赵春临1)高志军1)
1)郑州大学第一附属医院普外科;河南省高等学校临床医学重点学科开放实验室郑州4500522)郑州大学第一附属医院病理科郑州450052
Author(s):
QIAO Junbo1)ZHANG Xiefu1)LI Shanshan2)ZHAO Chunlin1)GAO Zhijun1)
1)Department of General Surgery,the First Affiliated Hospital,Zhengzhou University;KeyDisciplines Laboratory ClinicalMedicine Henan,Zhengzhou 4500522)Department of Pathology,the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
胃肿瘤腺癌层黏连蛋白受体Galectin3侵袭转移
Keywords:
gastric carcinoma67LRGalectin3invasionmetastasis
分类号:
R735.2
摘要:
了解胃癌组织中67000层黏连蛋白受体(67LR)和半乳糖凝集素3(Galectin3)蛋白的表达情况。方法:用免疫组织化学SP法检测82例胃癌组织和20例胃癌手术远端切缘正常胃组织中67LR蛋白和Galectin3蛋白的表达,并分析其与胃癌患者临床病理特征的关系。结果:胃癌组织中67LR蛋白的阳性表达率为59.8%,Galectin3蛋白的阳性表达率为84.1%,均高于相应的正常胃黏膜组织中的阳性表达率(30.0%和35.0%)。胃癌组织中67LR与Galectin3蛋白的阳性表达率与患者的年龄、性别、Lauren分型无关;67LR蛋白的阳性表达率与胃癌的组织分化程度有关(P<0.05),Galectin3蛋白的阳性表达率与胃癌的组织分化程度无关;有淋巴结转移的癌组织中两者的阳性表达率均高于无淋巴结转移组(P<0.05);随着肿瘤浸润深度的增加,两者的阳性表达率均明显增高(P<0.05)。胃癌组织中67LR与Galectin3的表达呈正相关(P<0.05)。结论:67LR及Galectin3蛋白阳性表达率与胃癌的侵袭、转移密切相关。
Abstract:
To study the expression of 67LR, galectin3, and their relationships in patients with gastric carcinoma.Methods:The expression of 67LR and galectin3 by immunohistochemical staining with the correspoding monoclonal antibodies, and their relation with the clinicopathologic characteristics were analyzed in 82 patients of primary gastric carcinoma. Gastric tissues were randomly collected from 20 patients as the controls which were gastric mucosas from the distant cutting margin.Results: The positive rate of expression of 67LR and galectin3 were 59.8%(49/82) and 84.1%(69/82) in gastric cancer cases, respectively, whereas the epithelial cells of gastric mucosas from the distant cutting margin had weak immunoreactivity which were 30.0% and 35.0%, respectively. The expression of 67LR and galectin3 in gastric carcinogen tissues were not related to gender, age, and Lauren classification.The expression phenotype of 67LR but not Galectin3 was correlated with cell differentiation. Moreover, the expression levels of 67LR and galectin3 were stronger in gastric cancerous tissues with lymph node metastasis than that in the tissues with no lymph node metastasis(P<0.05). Both of the 67LR and galectin3 expression levels were significantly increased with the depth of tumor invasion (P<0.05).Conclusion: The expression of 67LR and galectin3 might be closely associated with the invasion and metastasis of gastric cancer.

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备注/Memo

备注/Memo:
△男,1977年生,硕士研究生,研究方向:胃肠肿瘤,Email:junboqiao@sina.com #通讯作者,男,1957年生,教授,主任医师,研究方向:胃肠道肿瘤,Email:zhangxiefu@medmail.com.cn
更新日期/Last Update: 2010-05-18