[1]郭祯)△,刘林嶓)#,陈旻静).Ⅰ型神经纤维瘤病组织中蛋白激酶B、PTEN和ckit蛋白的表达[J].郑州大学学报(医学版),2009,(01):113-115.
 GUO Zhen),LIU Linbo),CHEN Minjing).Effect of PKB, PTEN and ckit on neurofibromatosis type Ⅰ pathogenesis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):113-115.
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Ⅰ型神经纤维瘤病组织中蛋白激酶B、PTEN和ckit蛋白的表达 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
113-115
栏目:
论著
出版日期:
2009-01-01

文章信息/Info

Title:
Effect of PKB, PTEN and ckit on neurofibromatosis type Ⅰ pathogenesis
作者:
郭祯1)刘林嶓2)#陈旻静2)
1)平顶山市第四人民医院整形外科平顶山4670002)郑州大学第一附属医院整形外科郑州450052
Author(s):
GUO Zhen1) LIU Linbo2) CHEN Minjing2)
1)Department of Plastic Surgery,the Forth Hospital of Pingdingshan, Pingdingshan 4670002)Department of Plastic Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
Ⅰ型神经纤维瘤病蛋白激酶BPTENckit
Keywords:
neurofibromatosis type 1protein kinase BPTENckit
分类号:
R739.4
摘要:
探讨Ⅰ型神经纤维瘤病(NF1)组织中蛋白激酶B(PKB)、PTEN和ckit的表达及意义。方法:应用免疫组织化学SP法检测26例NF1、20例孤立性神经纤维瘤和11例正常皮肤组织中磷酸化PKB(pPKB)、PTEN和ckit的表达情况。结果:正常皮肤组织中pPKB,ckit和PTEN的阳性表达率分别为9.1%,9.1%,100.0%;孤立性神经纤维瘤组织中3个指标的阳性表达率为55.0%,53.9,40.0%;NF1组织中3个指标的阳性表达率为60.0%,65.4%,43.3%。正常皮肤组织中3个指标的表达与后2种组织相比差异均有统计学意义(P<0.05);孤立性神经纤维瘤与NF1组织中3个指标的表达差异无统计学意义(P>0.05)。NF1组织中pPKB与PTEN的表达呈负相关(r=-0.456,P<0.05);pPKB与ckit的表达呈正相关(r=0.462,P<0.05)。结论:pPKB,PTEN和ckit可能与NF1的发展关系密切;NF1与孤立性神经纤维瘤的发展机制可能有相同之处。
Abstract:
To study the expression and the significance of PKB, PTEN and ckit proteins in NF1.Methods:The expressions of pPKB, PTEN and ckit were detected using immunohistochemistry on 26 cases of NF1, 20 cases of solitary neurofibroma and 11 cases of normal skin.Results: In normal skin the positive rates of pPKB, ckit, and PTEN were 9.1%, 9.1%, 100.0%; In solitary neurofibroma were 55.0%, 53.9%, 40.0%;In NF1 were 60.0%, 65.4%, 43.3%.The expressions of pPKB, PTEN and ckit in normal skin tissues were significantly different(P<0.05) compared with solitary neurofibroma and NF1. There were no significant differences in the expressions of pPKB, PTEN and ckit (P>0.05) between solitary neurofibroma and NF1. In NF1, pPKB expression was negatively correlated with PTEN (r=-0.456,P<0.05), and positively correlated with ckit(r=0.462, P<0.05).Conclusion: pPKB, PTEN and ckit may have close relationship with the development of NF1; The development mechanism of solitary neurofibroma and NF1 may be the same.

参考文献/References:

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备注/Memo

备注/Memo:
△女,1974年生,硕士,主治医师,研究方向:体表肿瘤,Email:guozhen04301926@126.com #通讯作者,男,1960年生,主任医师,教授,研究方向:体表肿瘤,Email:liulinbo@zzu.edu.cn
更新日期/Last Update: 2010-05-18