[1]蒋钰△,李春明.2型糖尿病患者餐后高甘油三酯血症对早期动脉粥样硬化形成的影响[J].郑州大学学报(医学版),2009,(01):140-142.
 JIANG Yu,LI Chunming.Relationship between postprandial hypertriglyceridemia and early atherosclerosis in type 2 diabetic patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):140-142.
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2型糖尿病患者餐后高甘油三酯血症对早期动脉粥样硬化形成的影响 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
140-142
栏目:
论著
出版日期:
2009-01-01

文章信息/Info

Title:
Relationship between postprandial hypertriglyceridemia and early atherosclerosis in type 2 diabetic patients
作者:
蒋钰李春明
江西省宜春学院医学院宜春336000
Author(s):
JIANG YuLI Chunming
Medical School, Yichun University,Yichun 336000
关键词:
2型糖尿病餐后高脂血症颈动脉内膜中层厚度
Keywords:
type 2 diabetes postprandial hyperlipidemia carotid artery intimamedia thickness
分类号:
R587.1
摘要:
探讨2型糖尿病患者餐后高甘油三酯血症对早期动脉粥样硬化形成的影响,为预防糖尿病大血管病变提供理论依据。方法:2型糖尿病患者95例,按空腹甘油三酯和脂肪餐试验4h后甘油三酯水平分为餐后正常组、餐后增高组、空腹高脂组,所有患者均测空腹血糖、餐后2h血糖、空腹血胰岛素、糖化血红蛋白、总胆固醇、甘油三酯、高密度脂蛋白胆固醇,低密度脂蛋白胆固醇、体质量指数、腰臀比、血压,计算胰岛素敏感指数,测量颈动脉内膜中层厚度。以颈动脉内膜中层厚度为因变量,其他指标为自变量,进行多元线性相关分析。结果:餐后增高组、空腹高脂组颈动脉内膜中层厚度分别为(1.23±0.64)mm、(1.12±0.63)mm,均高于餐后正常组[(0.75±0.63)mm](P<0.05),而餐后增高组与空腹高脂组颈动脉内膜中层厚度差异无统计学意义(P>0.05)。颈动脉内膜中层厚度与餐后4h血甘油三酯水平、空腹血胰岛素、体质量指数、腰臀比有相关性(P<0.01)。结论:2型糖尿病餐后高甘油三酯血症是导致早期动脉粥样硬化病变发生发展的一个重要危险因素。
Abstract:
To explore the effect of postprandial hypertriglyceridemia on the early atherosclerosis in type 2 diabetic patients,and to provide a theoretical basis for the clinical prevention of diabetic macroangiopathy.Methods:According to blood triglyceride(TG) level (fasting TG and TG 4 h),95 diabetic patients were divided into three groups:postprandial normal group, postprandial increased group, fasting highfat group. All patients’ fasting plasma glucose, postprandial 2hour blood glucose, fasting plasma insulin, HbAlc, total cholesterol, total triglycerides, highdensity lipoproteincholesterol, lowdensity lipoproteincholesterol, body mass index, waisthip ratio, blood pressure were measured; insulin sensitivity index was calculated;and carotid artery intimamedia thickness were measured.Correlation analysis between carotid artery intimamedia thickness and other parameters were performed.Results: Carotid artery intimamedia thickness in postprandial increased group and fasting highfat group were significantly higher than that in postprandial normal group (P<0.05),which had no difference between increased postprandial group and fasting highfat group(P>0.05);multiple correlation analysis showed that carotid artery intimamedia thickness was correlated with TG 4 h,fasting plasma insulin, BMI and WHR (P<0.01).Conclusion: Type 2 diabetes postprandial hypertriglyceridemia is an important risk factor leading to early atherosclerosis.

参考文献/References:

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备注/Memo

备注/Memo:
△女,1962年生,大学本科,教授,主任医师,研究方向:糖尿病及其慢性并发症的防治
更新日期/Last Update: 2010-05-18