[1]陈志敏,黄华,史惠蓉#.二甲双胍与罗格列酮治疗多囊卵巢综合征临床效果评价[J].郑州大学学报(医学版),2009,(01):164-165.
 CHEN Zhimin,HUANG Hua,SHI Huirong.Effects of metformin and roslglitazoneon in the treatment of polycystic ovarian syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):164-165.
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二甲双胍与罗格列酮治疗多囊卵巢综合征临床效果评价()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年01期
页码:
164-165
栏目:
论著
出版日期:
2009-01-01

文章信息/Info

Title:
Effects of metformin and roslglitazoneon in the treatment of polycystic ovarian syndrome
作者:
陈志敏黄华史惠蓉#
郑州大学第一附属医院妇产科郑州450052
Author(s):
CHEN Zhimin HUANG Hua SHI Huirong
Department of Obstetrics and Gynecology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
多囊卵巢综合征二甲双胍罗格列酮药物治疗
Keywords:
polycystic ovarian syndromemetforminroslglitazoneondrug therapy
分类号:
R711.75
摘要:
观察二甲双胍与罗格列酮对多囊卵巢综合征(PCOS)患者内分泌的影响,评估二者对PCOS的治疗价值。方法:选取71例有胰岛素抵抗及排卵障碍的PCOS患者,随机分为3组。A组(25例)用二甲双胍治疗12周后未排卵者加用克罗米酚治疗1个周期,B组(25例)用罗格列酮治疗12周后未排卵者加用克罗米酚治疗1个周期,C组(21例)单纯采用克罗米酚治疗。观察各组用药前后血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮、瘦素、空腹血糖、空腹胰岛素水平;并通过B超检查评价促排卵治疗的效果。结果:A、B、C组患者治疗前以上各指标差异无统计学意义;A、B组患者治疗后血清LH、睾酮、空腹胰岛素、IR值和瘦素水平与C组比较均下降(P<0.05),而FSH水平无变化;B组患者治疗后睾酮和IR值较A组患者明显下降(P<0.05)。C组患者排卵率和妊娠率均低于A、B2组(P<0.05)。结论:二甲双胍和罗格列酮可通过降低PCOS患者血清中胰岛素水平,纠正其高雄激素血症及生化指标异常,且可以加强克罗米酚促排卵治疗的疗效,提高妊娠率。
Abstract:
To investigate the endocrine effects of metformin and roslglitazoneon in the treatment of patients with polycystic ovarian syndrome (PCOS), and to evaluate the therapeutic value of these drugs in PCOS.Methods:Seventyone patients with PCOS concomitanted with insulin resisting (IR) and failure of ovulation were involved and randomly divided into three groups. Group A (25 cases) were treated with metformin for 12 weeks, and the ones who can not be induced ovulation by metformin were given clomiphene citrate (CC). Group B (25 cases) were treated with roslglitazoneon, and the patients without induced ovulation were given CC. Group C were only given CC as control. Serum folicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), fasting insulin (FINS), fasting leptin and IR were measured before and after treatment. The ovulation was screened by B ultrosonic.Results: The serum levels of FSH, LH, testosterone, fasting insulin, fasting leptin and IR among three groups were of no significant differences before treatment. After administration of metformin and roslglitazoneon, serum LH, T, leptin, FINS and IR decreased significantly in group A and B (P<0.05) compared with group C, but no significant differences were seen in the level of FSH. Testosterone and IR in group B were decreased significantly than that in group A after therapy (P<0.05). Ovulation and pregnancy rates in group C were lower than that in group A and B (P<0.05).Conclusion: Through decreasing level of serum fasting insulin, metformin and roslglitazoneon can correct enhanced testosterone and biochemical abnormalities in PCOS patients, enhance ovulation rate, and improve pregnancy rate.

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备注/Memo

备注/Memo:
#通讯作者,女,1956年生,博士,主任医师,教授,研究方向:妇科肿瘤,Email:huirongshi@yahoo.com.cn
更新日期/Last Update: 2010-05-18