[1]林锐)△,李晓丽),褚燕君).胃癌组织中诱导型一氧化氮合酶、核转录因子κB的表达[J].郑州大学学报(医学版),2009,(02):371-373.
 LIN Rui),LI Xiaoli),CHU Yanjun).Expression of iNOS and NFκB in human gastric carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):371-373.
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胃癌组织中诱导型一氧化氮合酶、核转录因子κB的表达 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年02期
页码:
371-373
栏目:
论著
出版日期:
2009-03-01

文章信息/Info

Title:
Expression of iNOS and NFκB in human gastric carcinoma tissue
作者:
林锐1)李晓丽2)褚燕君1)
1)郑州大学第一附属医院消化内科郑州4500522)郑州大学第一附属医院老年病科郑州450052
Author(s):
LIN Rui1)LI Xiaoli2)CHU Yanjun1)
1)Department of Digestive Disease,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Geriatrics,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
胃癌诱导型一氧化氮合酶核转录因子κB
Keywords:
gastric carcinomainducible nitric oxide synthasenuclear factorKappaB
分类号:
R735.2
摘要:
检测胃癌组织中诱导型一氧化氮合酶(iNOS)与核转录因子κB(NFκB)的表达。方法:采用免疫组织化学法检测53例胃癌和15例正常胃黏膜组织中iNOS及NFκB的表达情况。结果:胃癌组织中iNOS及NFκB的阳性表达率为71.70%、83.02%,均高于正常胃黏膜组织的13.33%、26.67%,差异有统计学意义(P均<0.05)。胃癌组织中iNOS及NFκB的表达与浸润深度和淋巴结转移有关(P均<0.05),且2者之间成正相关(r=0.642,P<0.01)。结论:iNOS及NFκB的高表达参与了胃癌的侵袭及转移。
Abstract:
To detect the expression of inducible nitric oxide synthase(iNOS) and nuclear factorKappaB(NFκB) in human gastric carcinoma tissue.Methods:Expression of iNOS and NFκB was examined by immunohistochemistry in 53 cases of gastric carcinoma tissue and 15 cases of normal gastric tissue.Results: The positive expression rate of iNOS and NFκB was significantly higher in gastric carcinoma tissue (71.70% and 83.02%) than those in normal gastric tissue (13.33% and 26.67%)(P<0.05).The expression of iNOS and NFκB in gastric carcinoma tissue was correlated with soaking deepth and lymph node metastasis(P<0.05). The expression of iNOS was positively correlated with that of NFκB(r=0.642,P<0.01).Conclusion: The overexpression of iNOS and NFκB might promote gastric carainogensis and also enhance the possibility of invasion and metastasis.

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备注/Memo

备注/Memo:
△男,1980年生,硕士研究生,主治医师,研究方向:消化道肿瘤
更新日期/Last Update: 2010-05-17