[1]袁志浩,乔保平#,李琦.肾癌组织中Livin和Smac蛋白的表达[J].郑州大学学报(医学版),2009,(02):397-398.
 YUAN Zhihao,QIAO Baoping,LI Qi.Expression of Livin and Smac in renal cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):397-398.
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肾癌组织中Livin和Smac蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年02期
页码:
397-398
栏目:
论著
出版日期:
2009-03-01

文章信息/Info

Title:
Expression of Livin and Smac in renal cell carcinoma tissue
作者:
袁志浩乔保平#李琦
郑州大学第一附属医院泌尿外科郑州450052
Author(s):
YUAN Zhihao QIAO Baoping LI Qi
Department of Urology, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
LivinSmac肾癌细胞凋亡
Keywords:
Livin proteinSmac proteinrenal cell carcinomaapoptosis
分类号:
R737.11
摘要:
探讨肾癌组织中Livin和Smac蛋白表达的意义。方法:应用免疫组织化学方法检测49例肾癌组织、18例癌旁组织和15例正常肾组织中Livin和Smac蛋白的表达情况。结果:肾癌组织、癌旁组织和正常组织中Livin蛋白阳性表达率分别为69.3%(34/49)、33.3%(6/18)和0%(0/15),依次降低(P<0.01);Smac阳性表达率分别为55.1%(22/49)、83.3%(15/18)、100%(18/18),依次升高(P<0.01)。肾癌组织中Livin和Smac蛋白的表达成负相关(rs=-0.332,P<0.05)。结论:Livin和Smac可能是肾癌细胞凋亡信号传导网络中的重要环节。
Abstract:
To explore the clinical significance of Livin and Smac expression in renal cell carcinoma (RCC) tissue.Methods:The expressions of Livin and Smac in 49 cases of RCC tissue, 18 cases of paracarcinoma tissue and 15 cases of normal renal tissue were detected by immunohistochemistry.Results: The positive rate of Livin in RCC, paracarcinoma, normal renal tissue was 69.3%(34/49),33.3%(6/18) , 0%(0/15) , respectively, and the positive rate of Smac in RCC, paracarcinoma, normal renal tissue was 55.1%(22/49),83.3%(15/18),100%(18/18), respectively. Contrast to nonRCC tissue,the expression of Livin in RCC tissue was significantly higher(P<0.01), and the expression of Smac in RCC tissue was significantly lower(P<0.01). The expression of Livin was negatively related to the expression of Smac in RCC tissues(rs=-0.332,P<0.05).Conclusion:These proteins might play an important role in the apoptosis pathway of the RCC cell.

参考文献/References:

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[5]Yan Y, Mahotka C, Heikaus S, et al. Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas[J].Br J Cancer, 2004,91(7):1 349
[6]Mizutani Y,Nakanishi H,Yamamoto K,et al.Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance[J].J Clin Oncol,2005,23(3):448
[7]Huerta S, Heinzerling JH, AnguianoHernandez YM,et al. Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf1, NFkappaB, IAPs, Smac/DIABLO, and AIF[J].J Surg Res,2007,42(1):184
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备注/Memo

备注/Memo:
#通讯作者,男,1965年生,教授,研究方向:泌尿系肿瘤,Email:yuan158@sina.com
更新日期/Last Update: 2010-05-17