[1]亓民)),李建生)#,马军),等.食管鳞状细胞癌组织中Ca125、Ca153、Ca199和Ca724的表达[J].郑州大学学报(医学版),2009,(03):478-480.
 QI Min)),LI Jiansheng),MA Jun),et al.Expressions of Ca125, Ca153, Ca199 and Ca724 in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):478-480.
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食管鳞状细胞癌组织中Ca125、Ca153、Ca199和Ca724的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
478-480
栏目:
食管癌研究
出版日期:
2009-05-01

文章信息/Info

Title:
Expressions of Ca125, Ca153, Ca199 and Ca724 in esophageal squamous cell carcinoma tissue
作者:
亓民1)2)李建生1)#马军3)李印4)
1)郑州大学第一附属医院消化科郑州4500522)洛阳市中心医院洛阳4710093)郑州大学消化疾病研究所郑州4500144)河南省肿瘤医院胸外科郑州450008
Author(s):
QI Min1)2) LI Jiansheng1) MA Jun3) LI Yin4)
关键词:
食管鳞状细胞癌Ca125Ca153Ca199Ca724
Keywords:
esophageal squamous cell carcinoma Ca125 Ca153 Ca199 Ca724
分类号:
R735.1
摘要:
检测食管鳞状细胞癌组织中Ca125、Ca153、Ca199和Ca724蛋白的表达。方法:采用组织芯片技术及免疫组织化学方法检测59例食管鳞状细胞癌及相应癌旁黏膜组织中Ca125、Ca153、Ca199和Ca724蛋白的表达情况。结果:食管鳞状细胞癌组织中Ca125、Ca153的阳性表达率分别为20.7%和44.8%,高于癌旁黏膜组织(2.2%和12.8%,P均<0.05);食管鳞状细胞癌组织中Ca724的阳性表达率为22.0%,低于癌旁黏膜组织(61.4%,P<0.05)。不同性别的食管癌患者癌组织中Ca153和Ca724的阳性表达率差异均有统计学意义(P<0.05)。结论:食管鳞状细胞癌的发生可能与Ca125、Ca153表达上调及Ca724表达下调有关;Ca153蛋白和Ca724蛋白的表达与性别有关。
Abstract:
To study the expressions of Ca125, Ca153, Ca199 and Ca724 in esophageal squamous cell carcinoma(ESCC) tissue.Methods:The expressions of Ca125, Ca153, Ca199 and Ca724 were detected by immunohistochemistry in tissue array consisting of 59 cases of ESCC and pericancer esophageal mucous tissue.Results: The positive expression rates of Ca125 and Ca153 in ESCC tissue were 20.7% and 44.8%,higher than those (2.2% and 12.8%) in pericancer esophageal mucous tissue(P<0.05), and that of Ca724 (22.0%) was lower than that (61.4%) in pericancer esophageal mucous tissue.There were relationships between gender and expressions of Ca153 and Ca724.

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备注/Memo

备注/Memo:
#通讯作者,男,1953年生,博士,教授,主任医师,研究方向:消化系统肿瘤
更新日期/Last Update: 2010-05-28