[1]张卫星,李松,王瑞#,等.精索静脉曲张不育患者精液质量、外周血生殖激素和精浆生化指标检测*[J].郑州大学学报(医学版),2009,(03):488-490.
 ZHANG Weixing,LI Song,WANG Rui,et al.Determination of semen quality, reproductive hormone and seminal plasma biochemical indicators in patients with varicocele infertility[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):488-490.
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精索静脉曲张不育患者精液质量、外周血生殖激素和精浆生化指标检测*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
488-490
栏目:
应用研究
出版日期:
2009-05-01

文章信息/Info

Title:
Determination of semen quality, reproductive hormone and seminal plasma biochemical indicators in patients with varicocele infertility
作者:
张卫星李松王瑞#韩广业李征张天标
郑州大学第一附属医院泌尿外科;河南省高等学校临床医学重点学科开放实验室;郑州大学肿瘤分子外科研究所郑州450052
Author(s):
ZHANG WeixingLI SongWANG RuiHAN GuangyeLI ZhengZHANG Tianbiao
关键词:
精索静脉曲张 精液分析生殖激素精浆生化
Keywords:
varicocele semen analysis reproductive hormoneseminal plasma biochemistry
分类号:
R698+.2
摘要:
探索精索静脉曲张(VC)致不育的可能机制。方法:采用放免法和酶免法检测69例VC不育患者和36例正常男性精液质量、生殖激素六项和精浆生化指标。结果:VC组精液密度、a级精子、精子活率、活力均低于正常对照组(P<0.05);VC组FSH[(7.13±4.48)IU/L]比正常对照组[(4.77±1.61)IU/L]明显升高(P<0.05),LH、PRL、E2、T、P 2组间差异均无统计学意义(P>0.05);精浆生化各项指标差异均无统计学意义(P>0.05)。结论:VC能够降低精液的密度、精子活力和活率,以影响睾丸生精细胞为主。FSH能够反映睾丸生精功能的下降,对判断VC不育患者的预后和指导治疗有一定意义。
Abstract:
To explore the possible mechanism of VCinduced infertility.Methods:Using radioimmunity method and zymoimmunity method to determine the semen quality,six items of reproductive hormone and seminal plasma biochemi cal indicators in 69 patients with VC infertility and 36 normal males.Results: The semen density,sperm cell of grade a,vitality and motility rate of VC group were all lower than those in normal control group(P<0.05).The level of FSH [(7.13±4.48) IU/L] in VC group was obviously higher than that [(4.77±1.61) IU/L] in normal control group(P<0.05),while LH,PRL,E2,T and P had no significant difference between the 2 groups(P>0.05).

参考文献/References:

[1]曹兴午,杨文质,赵广明.精液分析与不育症[M].北京:中国人口出版社,2006:238
[2]McClure RD,Khoo D,Jarvi K,et al.Subclinical varicocele:the effectiveness of varicoceletomy[J].J Urol,1991,145(4):789
[3]Goldstein M,Eid JF.Elevation of intratesticular and scrotal skin surface temperature in men with varicocele[J].J Urol,1989,142(3):743
[4]Bettella A,Merico M,Spolaore D,et al.Needle aspiration testicular cytology as diagnostic parameter in the assessment with varicocele[J]. Arch Ital Urol Androl,2001,73(1):3
[5]Su LM,Goldstein M,Schlegel PN.The effect of varicocelectomy on serum testosterone levels in infertile men with varicoceles [J].J Urol,1995,154(5):1 752
[6]Turner TT.The study of varicocele through the use of animal models[J].Hum Reprod Update,2001,7(1):78
[7]Crofton PM,Evans AE,Groome NP,et al.Inhibin B in boys from birth to adulthood: relationship with age,pubertal stage, FSH and testosterone[J].Clin Endocrinol,2002,56(2):215
[8]张卫星,王瑞,李培强.血清和精浆抑制素B在无精子症诊断中的应用研究[J].中华男科学杂志,2007,13(7):598
[9]Pasqualotto FF,Lucon AM,de Góes PM,et al.Semen profile,testicular volume,and hormonal levels in infertile patients with varicoceles compared with fertile men with and without varicoceles[J].Fertil Steril,2005,83(1):74

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备注/Memo

备注/Memo:
*河南省医学科技攻关基金资助项目20060037;河南省自然科学基金资助项目72102310025;河南省医学科技攻关基金资助项目200703014#通讯作者,男,1963年生,硕士,教授,研究方向:男科学,Email:huzi918@hotmail.com
更新日期/Last Update: 2010-05-28