[1]张进忠),蔡新华)#.风湿性心脏病合并慢性心房纤颤患者心房Ⅰ、Ⅲ型胶原蛋白的表达*[J].郑州大学学报(医学版),2009,(03):530-532.
 ZHANG Jinzhong),CAI Xinhua).Expression of typeⅠandⅢcollagen protein in patients with atrial fibrillation complicated with rheumatic heart disease[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):530-532.
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风湿性心脏病合并慢性心房纤颤患者心房Ⅰ、Ⅲ型胶原蛋白的表达*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
530-532
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expression of typeⅠandⅢcollagen protein in patients with atrial fibrillation complicated with rheumatic heart disease
作者:
张进忠1)蔡新华2)#
1)河南职工医学院医学生物学教研室郑州4511912)新乡医学院形态学研究室新乡453003
Author(s):
ZHANG Jinzhong1)CAI Xinhua2)
1)Department of Biology, Henan Medical College for Staff and Workers,Zhengzhou 4511912)Department of Morphologic Lab, Xinxiang Medical College, Xinxiang 453003
关键词:
Ⅰ、Ⅲ型胶原纤维 数字图像分析 心房纤颤风湿性心脏病
Keywords:
TypeⅠand Ⅲ collagen digital image analysis atrial fibrillationrheumatic heart disease
分类号:
R541.2
摘要:
探讨风湿性心脏病合并慢性心房纤颤患者心房胶原的组织学分布和Ⅰ、 Ⅲ型胶原蛋白表达的变化。方法:应用Masson和SP免疫组化染色方法,结合数字图像分析方法,观测4例正常人和6例风湿性心脏病合并慢性心房纤颤患者心房胶原的组织学分布和Ⅰ、 Ⅲ型胶原蛋白的表达。结果:Masson染色显示,风湿性心脏病合并慢性心房纤颤患者心房的部分区域心肌细胞间隙增大,胶原松散、断裂或大量聚集。正常心房Ⅰ、Ⅲ型胶原广泛分布,均可分为粗、细不等的条状纤维。风湿性心脏病合并慢性心房纤颤患者心房Ⅰ、Ⅲ型胶原表达大多区域正常,部分区域发生极度重排。
Abstract:
To investigate the changes of histological distribution of collagen and type Ⅰand Ⅲ collagen expression in atrium myocytes of patients with atrial fibrillation complicated with rheumatic heart disease.Methods:The histological distribution of collagen and expression of type Ⅰand Ⅲ collagen in human atrium of normal and patients was determined by Masson staining,immunohistochemistry and digitalimage analysis technology.

参考文献/References:

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[4]Keene DR,Sakai LY,Bachinger HP,et al.Type Ⅲ collagen can be present on banded collagen fibrils regardless of fibril diameter[J]. J Cell Biol,1987,105(5):2 393
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备注/Memo

备注/Memo:
*河南省自然科学基金资助项目20013100032#通讯作者,女,1963年生,硕士,副教授,研究方向:心脏分子细胞学,Email:cxh@xxmu.edu.cn
更新日期/Last Update: 2010-05-28