[1]李留霞△,石巍,乔玉环,等.妊娠期高血压孕妇胎盘组织中神经激肽B、胎盘生长因子的表达[J].郑州大学学报(医学版),2009,(03):554-557.
 LI Liuxia,SHI Wei,QIAO Yuhuan,et al.Expression and significance of neurokinin B and placenta growth factor in placentas with hypertensive disorder complicating pregnancy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):554-557.
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妊娠期高血压孕妇胎盘组织中神经激肽B、胎盘生长因子的表达 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
554-557
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expression and significance of neurokinin B and placenta growth factor in placentas with hypertensive disorder complicating pregnancy
作者:
李留霞石巍乔玉环王甜甜
郑州大学第一附属医院妇产科郑州450052
Author(s):
LI LiuxiaSHI WeiQIAO YuhuanWANG Tiantian
Department of Obstetrics and Gynecology,the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
神经激肽B胎盘生长因子妊娠期高血压疾病
Keywords:
Neurokinin BPlacenta growth factorHypertensive disorder complicating pregnancy
分类号:
R713.24+6
摘要:
探讨妊娠期高血压疾病(HDCP)孕妇胎盘组织中神经激肽B(NKB)、胎盘生长因子(PLGF)的表达及其与疾病发生发展的关系。方法:采用免疫组化法检测50例HDCP患者(妊娠期高血压患者15例,子疒间前期轻度患者15例,子疒间前期重度患者20例)及20例正常孕妇胎盘组织中NKB与PLGF蛋白定位及定量表达情况。结果:NKB蛋白及PLGF蛋白主要分布在绒毛合体滋养细胞和间质细胞的胞质,HDCP组胎盘NKB蛋白的表达高于正常组(平均灰度值分别为109.89±13.04和90.02±3.17,P<0.05),PLGF蛋白的表达低于正常组(平均灰度值分别为82.86±8.34和101.81±4.40,P<0.05);随着病情的加重,合体滋养细胞NKB的表达水平明显升高,PLGF表达水平明显降低(P<0.05)。结论:胎盘组织中NKB和PLGF蛋白的异常表达可能与HDCP的发生发展有关。

参考文献/References:

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备注/Memo

备注/Memo:
△女,1962年生,教授,主任医师,研究方向:妇科肿瘤、围产医学,Email:llxia698@yahoo.com.cn
更新日期/Last Update: 2010-05-28