[1]孙长宇),张贤强),江河清)#,等.肝细胞性肝癌组织中HBX蛋白与骨桥蛋白的表达[J].郑州大学学报(医学版),2009,(03):579-581.
 SUN Changyu),ZHANG Xianqiang),JIANG Heqing),et al.Expression of HBX and OPN in hepatocellular carcinoma and the clinical significances[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):579-581.
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肝细胞性肝癌组织中HBX蛋白与骨桥蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
579-581
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expression of HBX and OPN in hepatocellular carcinoma and the clinical significances
作者:
孙长宇1)张贤强1)江河清1)#杨观瑞2)
1)郑州大学第一附属医院感染科郑州4500522)河南省医药科学研究院肿瘤研究室郑州450052
Author(s):
SUN Changyu1)ZHANG Xianqiang1)JIANG Heqing1)YANG Guanrui2)
1)Department of Infection,the First Affiliated Hospital,Zhengzhou University, Zhengzhou 4500522)Department of Oncology,Henan Academy of Medical and Pharmaceutical Sciences,Zhengzhou 450052
关键词:
肝细胞性肝癌乙型肝炎病毒X基因骨桥蛋白
Keywords:
Hepatocellular carcinomaHepatitis B virus X geneOsteopontin
分类号:
R735.7
摘要:
了解肝细胞性肝癌(HCC) 组织中HBX蛋白与骨桥蛋白(OPN)的表达情况。方法:采用免疫组化方法检测49例肝细胞性肝癌组织(其中高分化12例,中分化21例,低分化16例;伴肝硬化9例,甲胎蛋白阳性33例;有淋巴结转移、肝内转移、门静脉癌栓或远处转移者29例)、癌旁组织及10例乙型肝炎标志物阳性的正常肝组织中HBX蛋白与OPN的表达情况,分析二者在HCC组织和癌旁组织中的相关性。结果:HCC组织中HBX蛋白与OPN蛋白的阳性表达率分别为69.4%与81.6%,癌旁组织中分别为57.1%与71.4%,均明显高于正常肝组织(χ2分别为20.051和27.579;P<0.05); HBX与OPN在HCC组织及癌旁组织的表达呈正相关,相关系数分别为0.516和0.426;有转移与无转移组间HBX与OPN蛋白的表达差异均有统计学意义 (χ2分别为5.890和6.235;P<0.05)。结论:HBX蛋白与OPN在HCC的发生发展与转移中具有重要作用。
Abstract:
To study the difference of OPN and HBX expressions in normal liver,adjacent nontumorous tissues and primary hepatocellular carcinoma(HCC),and the effects in the carcinogenesis of HCC.Methods:OPN and HBX expressions in 49 cases of HCC with adjacent nontumorous tissues and 10 cases of normal liver tissues were detected by immunohistochemistry.

参考文献/References:

[1]Tang ZY.Hepatocellular carcinomacause,treatment and metastasis[J].World J Gastroenterol,2001,7(4):445
[2]Omata M,Yoshida H.Prevention and treatment of hepatocellular carcinoma[J].Liver Transpl,2004,10(2 Suppl 1):S111
[3]Gurtsevitch VE.Human oncogenic viruses:hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis[J].Biochemistry(Mosc),2008,73(5):504
[4]Sirma H, Giannini C, Poussin K,et al. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx[J].Oncogene,1999,18(34):4 848
[5]Weber GF, Ashkar S, Glimcher MJ, et al.Receptorligand interaction between CD44 and osteopontin (Eta1)[J].Science,1996,271(5 248):509
[6]Fromowitz FB,Viola MV,Chao S,et al.ras p2l expression in the progession of breast cancer[J].Hum Pathol,1987,18(12):1 268
[7]王小众,陶其敏.乙肝病毒x基因与肝癌[J].世界华人消化杂志,1999,7(12):1 063
[8]Lee TH,Finegold MJ,Shen RF,et al.Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice[J].J Virol,1990,64(12):5 939
[9]Feitelson MA,Duan LX.Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma[J].Am J Pathol,1997,150(4):1 141
[10]丁海,薛迪广,刘伟.乙肝x基因在原发性肝癌中表达的临床研究[J].肝胆外科杂志,2002,10(5):385
[11]Weber GF. The metastasis gene osteopontin: a candidate target for cancer therapy[J].Biochim Biophys Acta,2001,1 552(2):61

相似文献/References:

[1]孙长宇)△,张贤强),杨观瑞).肝细胞癌组织中乙型肝炎病毒X基因、COX2及MMP9的表达[J].郑州大学学报(医学版),2009,(01):96.
 SUN Changyu),ZHANG Xianqiang),YANG Guanrui).Expression of HBX,COX2 and MMP9 in hepatocellular carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):96.

备注/Memo

备注/Memo:
#通讯作者,女,1946年生,教授,研究方向:乙肝相关性肝癌的防治,Email:jiangheqing2004@126.com
更新日期/Last Update: 2010-05-28