[1]高黎)△,王国芳),季旭东),等.口腔黏膜白斑及鳞癌组织中核因子κBp65与PCNA的表达[J].郑州大学学报(医学版),2009,(03):582-584.
 GAO Li),WANG Guofang),JI Xudong),et al.Expression of NFκB p65 and PCNA during oral leukoplakia carcinogenesis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):582-584.
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口腔黏膜白斑及鳞癌组织中核因子κBp65与PCNA的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
582-584
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expression of NFκB p65 and PCNA during oral leukoplakia carcinogenesis
作者:
高黎1)王国芳1)季旭东1)马丽华1)张彦喜1)石爱梅2)
1)郑州大学第四附属医院口腔科郑州4500522)郑州大学第一附属医院口腔科郑州450052
Author(s):
GAO Li1)WANG Guofang1)JI Xudong1)MA Lihua1)ZHANG Yanxi1)SHI Aimei2)
1)Department of Stomatology,the Forth Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522)Department of Stomatology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
口腔白斑口腔鳞状细胞癌 核因子κB增殖细胞核抗原
Keywords:
Oral Leukoplakia oral squamous cell carcinomaNuclear Factor gene bindingPCNA
分类号:
R739.85
摘要:
探讨口腔黏膜白斑(OLK)及鳞癌(OSCC)组织中核因子κB p65及增殖细胞核抗原(PCNA)的表达情况。方法:应用免疫组织化学技术检测正常口腔黏膜上皮(n=10)、单纯增生型OLK(n=11)、异常增生型OLK(n=35)、OSCC(n=36)组织中的NFκB p65和PCNA的表达情况。结果:正常口腔黏膜上皮组织中p65不表达,由单纯增生型OLK转变到异常增生型OLK最后到OSCC的发生发展过程中NFκB p65的表达明显上调(9.1%,42.9%,72.2%),差异有统计学意义(χ2=30.323,P<0.05);正常口腔黏膜、OLK组织和OSCC组织中均有PCNA阳性表达,且增殖指数逐渐升高(4.90±1.18,6.45±2.03,28.43±13.91,63.89±15.31),差异有统计学意义(F=21.55,P<0.05)。二者在OLK癌变过程中密切相关。结论:二者可能是检测OLK恶变潜能及OSCC早期诊断的敏感指标。
Abstract:
To investigate the expression of NFκB p65 and PCNA as well as their relation in Oral Leukoplakia (OLK) and oral squamous cell carcinoma (OSCC),then to evaluate their functions in tumorigenesis and progession of OSCC.Methods:Immunohistochemical staining technique was used to determine the expression NFκB p65 and PCNA in all specimens: 10 cases of normal human oral epithelium,11simple hyperplasis OLK,35 dysplasia OLK,and 36 OSCC.

参考文献/References:

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备注/Memo

备注/Memo:
△女,35岁,硕士,主治医师,研究方向:口腔黏膜疾病的诊治,Email:gaolidoc@126.com
更新日期/Last Update: 2010-05-28