[1]冯才政),王树凯)#,张军喜),等.脑胶质瘤组织中Survivin和尿激酶型纤溶酶原激活物蛋白的表达[J].郑州大学学报(医学版),2009,(03):585-587.
 FENG Caizheng),WANG Shukai),ZHANG Junxi),et al.Expressions of Survivin and uPA in human cerebral gliomas[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):585-587.
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脑胶质瘤组织中Survivin和尿激酶型纤溶酶原激活物蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
585-587
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expressions of Survivin and uPA in human cerebral gliomas
作者:
冯才政1)王树凯1)#张军喜2)李海春1)丁攀峰1)
1)郑州大学第一附属医院神经外科郑州4500522)河南省人口和计划生育科学技术研究院郑州450002
Author(s):
FENG Caizheng1)WANG Shukai1) ZHANG Junxi2)LI HaiChun1)DING Panfeng1)
1)Department of Neurosurgery,the First Affiliated Hospital,Zhengzhou University, Zhengzhou 4500522)Population and Family Planning Research Institute Of Henan Province,Zhengzhou 450002
关键词:
胶质瘤Survivin尿激酶型纤溶酶原激活物
Keywords:
gliomasurvivinurokinasetype plasminogen activator
分类号:
R739.4
摘要:
探讨脑胶质瘤组织中Survivin蛋白和尿激酶型纤溶酶原激活物(uPA)的表达及二者的关系。方法:应用免疫组化SP法检测68例脑胶质瘤标本和10例正常脑组织中Survivin和uPA的表达及分布情况。结果:正常脑组织中均未见Survivin和uPA阳性表达;ⅠⅡ级与Ⅲ、Ⅳ级脑胶质瘤组织中Survivin蛋白的阳性表达率分别为24.6%、57.1%和84.3%,差异有统计学意义( χ2=11.5,P<0.05);uPA蛋白的阳性表达率分别为58.6%,90.5%和94.4%;差异有统计学意义(χ2=10.9,P<0.05);在胶质瘤组织中Survivin和uPA的表达成正相关(r=0.519, P<0.05)。结论:脑胶质瘤组织中uPA和Survivin蛋白呈高表达,2者与脑胶质瘤恶性程度密切相关。
Abstract:
To investiage the expressions of Survivin and uPA in human cerebral gliomas,as well as the correlation between them and tumor cells apoptosis and invasive growth of human cerebral gliomas.Methods:The expressions and distribution of Survivin and uPA were determined by Immunohistochemical tecnique(SP)in 68 cases of human cerebral gliomas and 10 cases of normal brain tissues.

参考文献/References:

[1]Jiao BH, Yao ZG, Ceng SM, et al. Expression of survivin,a novel apotosis inhibitor and cell regulator protein, in human gliomas[J].Chin Med J,2004,117(4):612
[2]Pan Y, Hu WH, Xie D,et al. Nuclear and cytoplasmic expressions of survivin in glioma and their prognostic value[J]. Zhonghua Yi Xue Za Zhi,2007,87(5):325
[3]Sandler A, Scott D,Azuhata T,et al. The survivin:Fas ratio is predictive of recurrent disease in neuroblastoma[J]. J Pediatr Surg,2002,37(3):507
[4]Uchdia H, Tanaka T, Sasaki K,et al. Adenovirus mediated transfer of siRNA against suivivin induced apotosis and attenuated tumor cell growth in vitro and in vivo[J]. Mol Ther,2004,10(1):162
[5]许先平, 吴明灿, 陈世洁,等.胶质瘤中survivin蛋白表达及生物学意义[J].长江大学学报:医学卷,2007,4(1):8
[6]Gondi CS, Lakka SS, Yanamandra N, et al. Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis[J]. Oncogene,2003,22(38):5 967
[7]Gondi CS, Lakka SS, Dinh DH, et al. Intraperitoneal injection of a hairpin RNAexpressing plasmid targeting urokinasetype plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice[J]. Clin Cancer Res,2007,13(14):4 051
[8]陈伟, 陈谦学, 王军民,等. NFκB和uPA在人脑胶质瘤中的表达[J].中国临床神经外科杂志,2007,12(2):83

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备注/Memo

备注/Memo:
#通讯作者,男,1956年生,硕士,主任医师,研究方向:神经外科基础与临床
更新日期/Last Update: 2010-05-28