[1]赵玉林△,赵琳.鼻息肉组织中肝细胞生长因子及血管内皮生长因子的表达[J].郑州大学学报(医学版),2009,(03):591-593.
 ZHAO Yulin,ZHAO Lin.Expression of hepatocyte growth factor and vascular endothelial growth factor in nasal polyps[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):591-593.
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鼻息肉组织中肝细胞生长因子及血管内皮生长因子的表达 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
591-593
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expression of hepatocyte growth factor and vascular endothelial growth factor in nasal polyps
作者:
赵玉林赵琳
郑州大学第一附属医院耳鼻咽喉科郑州450052
Author(s):
ZHAO Yulin ZHAO Lin
Department of Otorhinolaryngology, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
鼻息肉肝细胞生长因子血管内皮生长因子
Keywords:
nasal polyps hepatocyte growth factor vascular endothelial growth factor
分类号:
R765.25
摘要:
检测鼻息肉组织中肝细胞生长因子(HGF)及血管内皮生长因子(VEGF)的表达。方法:采用免疫组织化学方法分别检测30例鼻息肉标本和20例正常下鼻甲黏膜标本中HGF与 VEGF的表达。结果:鼻息肉组织中可见大量嗜酸性粒细胞浸润。鼻息肉组织中HGF和VEGF蛋白的阳性表达率分别为83.3%和76.7%,均高于正常对照组(30.0%和10.0%,P<0.05),且在鼻息肉血管内皮细胞及间质浸润的炎症细胞中2者的表达呈正相关(r=0.630,P<0.05;r=0.514,P<0.05)。结论:鼻息肉组织中HGF和VEGF的表达增强,提示2者可能协同参与鼻息肉的形成。
Abstract:
To evaluate the relationship between the expression of hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) in nasal polyp(NP) tissue.Methods: HE staining and immunohistochemical assay were carried out in 30 cases of NP tissue and normal inferior turbinate (IT) tissue to detect the expression of VEGF and HGF.

参考文献/References:

[1]Ishibashi T, Tanaka T, Nibu K, et al. Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps[J]. Ann Otol Rhinol Laryngol,1998,107(10):885
[2]Coste A, Brugel L, Maitre B, et al. Inflammatory cells as well as epithelial cells in nasal polyps express vascular endothelial growth factor[J]. Eur Respir J,2000,15(2):367
[3]Morishita R, Moriguchi A, Higaki J, et al. Hepatocyte growth factor (HGF) as a potential index of severity of hypertension [J]. Hypertens Res, 1999, 22(3):161
[4]中华医学会耳鼻咽喉科学分会,中华耳鼻咽喉科杂志编辑委员会.慢性鼻窦炎鼻息肉临床分型分期及内窥镜鼻窦手术疗效评定标准(1997年,海口)[J].中华耳鼻咽喉科杂志,1998,33(3):134
[5]郑丰平,袁世珍,冯智英,等.TSP、VEGF与大肠癌血管生成、转移关系的研究[J].实用肿瘤科杂志,2000,15(6):394
[6]Rho HS,Lee SH, Lee HM, et al. Overexpression of hepatocyte growth factor and its receptor cMet in nasal polyps [J].Arch Otolaryngol Head Neck Surg,2006,132(9):985
[7]Fujisaki T, Tanaka Y, Fujii K, et al. CD44 stimulation induces integrinmediated adhesion of colon cancer cell lines to endothelial cells by upregulation of integrins and cMet and activation of integrins[J].Cancer Res,1999, 59(17):4 427

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备注/Memo

备注/Memo:
△男,1964年生,教授,主任医师,研究方向:鼻腔鼻窦黏膜病及其微创外科,Email:zhaoyulinmail@163.com
更新日期/Last Update: 2010-05-28