[1]田辉英),杨志浩),高剑波)#,等.胃癌组织中VEGFD、VEGFR3mRNA表达与SCT征象的关系[J].郑州大学学报(医学版),2009,(03):611-612.
 TIAN Huiying),YANG Zhihao),GAO Jianbo),et al.Relationship between spiral CT features of gastric carcinoma and expression of VEGFD, VEGFR3 mRNA[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):611-612.
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胃癌组织中VEGFD、VEGFR3mRNA表达与SCT征象的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
611-612
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Relationship between spiral CT features of gastric carcinoma and expression of VEGFD, VEGFR3 mRNA
作者:
田辉英1)杨志浩1)高剑波1)#陈奎生2)郭华1)
1)郑州大学第一附属医院放射科郑州4500522)郑州大学第一附属医院病理科郑州450052
Author(s):
TIAN Huiying1) YANG Zhihao1) GAO Jianbo1) CHEN Kuisheng2) GUO Hua1)
1)Department of Radiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522)Department of Pathology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
胃肿瘤体层摄影术X线计算机VEGFDVEGFR3
Keywords:
gastric neoplasm Xray computed tomography VEGFDVEGFR3
分类号:
R735.2
摘要:
探讨胃癌螺旋CT表现与VEGFD、VEGFR3 mRNA表达的关系。方法:对59例进展期胃癌患者于手术前1周内行SCT平扫及三期动态增强扫描,术后采用原位杂交法检测肿瘤组织标本中VEGFD、VEGFR3 mRNA的表达。结果:VEGFD mRNA在淋巴结转移组的表达率(70.00%)高于未转移组(36.84%),在弥漫型组的表达率(72.97%)高于肠型组(40.91%),在T2期组的表达率(27.27%)低于T34期组(72.92%),差异均有统计学意义(P<0.05);VEGFR3 mRNA在淋巴结转移组的表达率(77.50%)高于未转移组(31.58%),在弥漫型组的表达率(78.38%)高于肠型组(45.45%),在T2期组的表达率(36.36%)低于T34期组(77.08%),差异均有统计学意义(P<0.05)。胃癌组织中2者的表达呈正相关(rs=0.502,P<0.05)。

参考文献/References:

[1]Stacker SA, Caesar C, Bakjwin ME, et al. VEGFD promotes the metastatic spread of tumor cells via the lymphatics[J]. Nat Med, 2001,7(2):186
[2]Karkkainen MJ, Petrova TV. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis[J]. Oncogene, 2000,19(49): 5 598
[3]Saaristo A, Partanen TA, Arola J, et al. Vascular endothelial growth factorC and its receptor VEGFR3 in the nasal mucosa and in nasopharyngeal tumors[J]. Am J Pathol, 2000,157(1):7
[4]Juttner S, Wissmann C, Jons T, et al. Vascular endothelial growth factorD and its receptor VEGFR3: two novel independent prognostic markers in gastric adenocarcinoma[J]. J Clin Oncol,2006,24(2):228

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备注/Memo

备注/Memo:
#通讯作者,男,1964年生,博士,教授,研究方向:消化道肿瘤
更新日期/Last Update: 2010-05-28