[1]肖兴国),温洪涛)#,张蕾),等.胃腺癌组织中Ets1及微血管密度检测[J].郑州大学学报(医学版),2009,(03):622-624.
 XIAO Xingguo),WEN Hongtao),ZHANG Lei),et al.Detection of Ets1 proteins and MVD in gastric adenocarcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):622-624.
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胃腺癌组织中Ets1及微血管密度检测()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
622-624
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Detection of Ets1 proteins and MVD in gastric adenocarcinoma
作者:
肖兴国1)温洪涛1)#张蕾2)张云汉3)
1)郑州大学第一附属医院消化内科郑州4500522)郑州大学第一附属医院肿瘤科郑州4500523)郑州大学第一附属医院病理科郑州450052
Author(s):
XIAO Xingguo1)WEN Hongtao1)ZHANG Lei2)ZHANG Yunhan3)
关键词:
Ets1微血管密度胃肿瘤侵袭转移
Keywords:
Ets1 MVDgastricneoplasminvasionmetastasis
分类号:
R735.2
摘要:
研究转录调节因子 Ets1(E26 transformation specific1)及微血管密度(MVD)在胃腺癌组织中的表达及意义。方法:采用免疫组织化学SP法检测Ets1和MVD在28例正常胃黏膜、40例不典型增生胃黏膜及70例胃腺癌组织中的表达。结果:胃腺癌组织中Ets1阳性表达率(87.1%)明显高于癌旁病变组织(57.5%)和正常胃黏膜(32.1%) (P均<0.05);CD105标记的MVD均值(30.16±3.92)明显高于癌旁病变组织(12.98±1.62)和正常胃黏膜(11.29±1.08)(P均<0.05)。 胃腺癌组织中 Ets1的表达和MVD均值与胃腺癌浸润深度、淋巴结转移及临床分期有关(P均<0.05),与年龄和性别无关(P均>0.05)。胃腺癌组织中MVD值随着Ets1表达增强而增高(P<0.05)。结论:高表达的Ets1参与胃腺癌浸润和淋巴道转移,并与胃腺癌组织中微血管生成有关,Ets1可作为判断胃腺癌恶性行为的重要生物学标记物之一。
Abstract:
To explore the expression of Ets1 and MVD and their correlation with clinic pathological parameters in gastric carcinoma.Methods:The expression of Ets1 and MVD were detected by immunohistochemistry in normal gastric mucosa (n=28),gastric hyperplasia (n=40) and gastric carcinoma (n=70).

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1968年生,教授,主任医师,研究方向:消化道肿瘤的基础与临床研究,Email:wenhongtao68@163.com
更新日期/Last Update: 2010-05-28