[1]单岩))△,张谦),刘章锁).褪黑素在大鼠慢性肾功能衰竭进展中对肾组织细胞增殖和凋亡的影响[J].郑州大学学报(医学版),2009,(03):629-632.
 SHAN Yan)),ZHANG Qian),LIU Zhangsuo).The effect and significance of melatonin on proliferation and apoptosis in rats during the process of chronic renal failure[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):629-632.
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褪黑素在大鼠慢性肾功能衰竭进展中对肾组织细胞增殖和凋亡的影响 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
629-632
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
The effect and significance of melatonin on proliferation and apoptosis in rats during the process of chronic renal failure
作者:
单岩1)2)张谦3)刘章锁1)
1)郑州大学第一附属医院肾内科郑州4500522)郑州大学护理学院郑州4500523)郑州大学第一附属医院小儿外科郑州450052
Author(s):
SHAN Yan1)2)ZHANG Qian3) LIU Zhangsuo1)
关键词:
慢性肾功能衰竭褪黑素凋亡增殖
Keywords:
chronic renal failuremelatoninapoptosisproliferation
分类号:
R364.1
摘要:
研究褪黑素(MEL)在大鼠慢性肾功能衰竭进展中对肾组织细胞增殖、凋亡的影响和意义。方法:150只SD大鼠,随机分为3组:CTL组(假手术组)、STN组(5/6肾切除组)、MEL组(5/6肾切除+MEL使用组)。MEL使用40周,分别于1周、2周、8周、12周、16周和40周共6个不同的时间点采用免疫组化和TUNEL法检测增殖细胞核抗原(PCNA)表达与肾组织细胞凋亡的情况。结果:STN组:肾小球系膜区、肾小管术后2~12周内增殖指数较CTL组显著升高(P<0.05),术后16~40周内凋亡指数较CTL组显著升高(P<0.05), 术后2~8周内增殖/凋亡比值较CTL组显著升高(P<0.05);肾间质在术后增殖指数持续升高,与CTL组比较,差异显著(P<0.05),其凋亡不明显,增殖/凋亡比值在术后16周内较CTL组显著升高(P<0.05)。

参考文献/References:

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备注/Memo

备注/Memo:
△女,1969年生,博士研究生,副教授,研究方向:肾功能衰竭,Email:sy110@sina.com
更新日期/Last Update: 2010-05-28