[1]王跃)△,吕文伟),李燕芳).肾透明细胞癌组织中转化生长因子β1和磷酸化细胞外信号调节激酶的表达[J].郑州大学学报(医学版),2009,(03):633-635.
 WANG Yue),LV Wenwei),LI Yanfang).Expression of transforming growth factor β1 and phosphorylated activated extracellular signalregulated kinase in renal clear cell carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):633-635.
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肾透明细胞癌组织中转化生长因子β1和磷酸化细胞外信号调节激酶的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年03期
页码:
633-635
栏目:
论著
出版日期:
2009-05-01

文章信息/Info

Title:
Expression of transforming growth factor β1 and phosphorylated activated extracellular signalregulated kinase in renal clear cell carcinoma
作者:
王跃1)吕文伟2)李燕芳3)
1)郑州大学第一附属医院肾移植科郑州4500522)郑州大学第一附属医院泌尿外科郑州4500523)焦作煤业集团中央医院急诊科焦作454150
Author(s):
WANG Yue1)LV Wenwei2)LI Yanfang3)
关键词:
肾透明细胞癌转化生长因子β1磷酸化细胞外信号调节激酶
Keywords:
renal clear cell carcinoma transforming growth factor β1 phosphorylated activated extracellular signalregulated kinase
分类号:
R737.11
摘要:
探讨肾透明细胞癌(RCCC)组织中转化生长因子β1(TGFβ1)和磷酸化细胞外信号调节激酶(pERK)的表达及其临床意义。方法:采用免疫组织化学SP法检测72例肾透明细胞癌组织和30例正常肾组织中TGFβ1和pERK蛋白的表达,分析其与RCCC临床病理特征的关系。结果:①RCCC组织中TGFβ1和pERK阳性率分别为70.2%和78.1%,均高于正常肾组织22.6%和16.7%(P均<0.05),2者的表达呈正相关(r=0.443,P<0.05)。②TGFβ1和PERK的表达与RCCC组织分化程度和TNM分期有关(P<0.05)。结论:TGFβ1和p ERK可能在肾透明细胞癌的发生发展过程中发挥重要作用。
Abstract:
To investigate the expression of transforming growth factor β1(TGFβ1) and phosphorylated activated extracellular signalregulated kinase(pERK) and their clinical significance in renal clear cell carcinoma(RCCC).Methods:The expression of TGFβ1 and pERK was detected in 72 cases of RCCC tissue and 30 cases of nomal renal tissue by immunohistochemical method.

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备注/Memo

备注/Memo:
△男,1959年生,教授,主任医师,研究方向:肾移植及肾肿瘤,Email:wangyue@zzu.edu.cn
更新日期/Last Update: 2010-05-28