[1]谢新纪),郭涛),王立东)#,等.河南食管癌高发区反流性食管炎患者食管上皮组织病理学变化特征*[J].郑州大学学报(医学版),2009,(04):703-704.
 XIE Xinji),GUO Tao),WANG Lidong)etc.Histopathological changes of esophageal epithelium of patients with reflux esophagitis at highincidence area for esophageal cancer in Henan[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):703-704.
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河南食管癌高发区反流性食管炎患者食管上皮组织病理学变化特征*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
703-704
栏目:
食管癌研究
出版日期:
2009-07-01

文章信息/Info

Title:
Histopathological changes of esophageal epithelium of patients with reflux esophagitis at highincidence area for esophageal cancer in Henan
作者:
谢新纪1)郭涛2)王立东2)#王海艳2)王晗晶2)冯常炜3)张延瑞4)
1)首都医科大学附属北京同仁医院消化内科 北京 1007302)河南省食管癌重点开放实验室;郑州大学第一附属医院;郑州大学基础医学院 郑州 4500523)郑州大学第二附属医院消化内科 郑州 4500144)河南省人民医院消化内科 郑州 450003
Author(s):
XIE Xinji1) GUO Tao2)WANG Lidong2)etc
关键词:
反流性食管炎食管癌高发区
Keywords:
reflux esophagitis esophageal cancer high incidence areas
分类号:
R735.1
摘要:
探讨河南食管癌高发区反流性食管炎(RE)患者食管上皮组织病理变化的特征。方法:对临床内镜诊断的86例RE患者及61例正常对照的食管黏膜活检组织进行组织病理学观察。结果:RE患者食管上皮基底细胞过度增生、间变、乳头升高发生率分别为64%(55/86)、20%(17/86)和76%(65/86),高于对照组的30%(18/61)、0(0/61)和20%(12/61)(P均<0.05);RE组乳头密度(3.7±2.8)个/mm,高于对照组的(1.2±1.0)个/mm(t=8.28,P<0.05)。结论:基底细胞过度增生、间变、固有膜乳头升高和增生是河南食管癌高发区RE患者的基本病理改变。
Abstract:
To characterize the histopathological changes of esophageal epithelium of reflux esophagitis (RE) patients from the highincidence areas for esophageal cancer in Henan.Methods:A total of 86 cases of RE diagnosed by endoscopic examination and 61 cases of normal control from the highincidence areas for esophageal cancer in Henan were collected to observe the changes of esophageal epithelium.Results: The detection rates of basal cell hyperplasia, dysplasia, papillae elongation and proliferation (the number of papillae increased) were 64%(55/86),20%(17/86),76%(65/86),respectively,those of the control were 30%(18/61),0(0/61) and 20%(12/61),respectively.The detection rats of RE pateints were all higher than those of the control(P<0.05).The papillae density in RE group was(3.7±2.8) mm-1,higher than that in control group (1.2±1.0) mm-1 (t=8.28,P<0.05).Conclusion: Basal cell hyperplasia, dysplasia, papillae elongation and proliferation are fundamental pathological changes for RE.

参考文献/References:

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备注/Memo

备注/Memo:
*河南省高校科技创新团队基金资助项目2008080411#通讯作者,王立东,男,1958年生,博士,教授,研究方向:食管和贲门癌变机制和防治,Email:ldwang@zzu.edu.cn#通讯作者,刘宾,女,1944年生,教授,研究方向:消化道肿瘤的发病机制和防治,Email:l.b.44@medmail.com.cn
更新日期/Last Update: 2010-05-18