[1]师秀琴),徐嵩龄),李醒亚)#.新辅助化疗对食管鳞状细胞癌组织中趋化因子受体7和血管内皮生长因子C表达的影响[J].郑州大学学报(医学版),2009,(04):705-707.
 SHI Xiuqin),XU Songling),LI Xingya).Effect of neoadjuvant chemotherapy on the expressions of CCR7 and VEGFC in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):705-707.
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新辅助化疗对食管鳞状细胞癌组织中趋化因子受体7和血管内皮生长因子C表达的影响 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
705-707
栏目:
食管癌研究
出版日期:
2009-07-01

文章信息/Info

Title:
Effect of neoadjuvant chemotherapy on the expressions of CCR7 and VEGFC in esophageal squamous cell carcinoma tissue
作者:
师秀琴1)徐嵩龄2)李醒亚3)#
1)郑州大学第一附属医院药剂科 郑州 4500522)郑州大学第三附属医院超声科 郑州 4500523)郑州大学第一附属医院肿瘤科 郑州 450052
Author(s):
SHI Xiuqin1)XU Songling2) LI Xingya3)
1)Department of Pharmacy, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 4500522)Department of Ultrasound, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou 4500523)Department of Oncology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
食管肿瘤鳞状细胞癌新辅助化疗趋化因子受体7 血管内皮生长因子C
Keywords:
esophageal neoplasmsquamous cell carcinomaneoadjuvant chemotherapyCCR7VEGFC
分类号:
R735.1
摘要:
探讨新辅助化疗对食管鳞状细胞癌组织中趋化因子受体7(CCR7)和血管内皮生长因子C(VEGFC)表达的影响。方法:25例食管癌患者(新辅助化疗组)术前进行化疗2周期后手术;与新辅助化疗组初诊时期别相同的食管癌患者45例(单纯手术组)术前均未进行化疗和放疗。用免疫组织化学SP法测定手术切除标本中CCR7和VEGFC的表达,并进行分析。结果:新辅助化疗组淋巴结转移率和CCR7、VEGFC阳性率分别为24.0%(6/25)、48.0%(12/25)和20.0%(5/25),单纯手术组分别为55.6%(25/45)、75.6%(34/45)和68.9%(31/45),新辅助化疗组淋巴结转移率、CCR7和VEGFC阳性率均低于单纯手术组(χ2分别为6.48,5.41,15.28,P均<0.05)。单纯手术组CCR7蛋白与VEGFC蛋白表达呈正相关(rs=0.623,P<0.05)。结论:新辅助化疗可能通过下调组织中CCR7和VEGFC的表达,从而减少食管鳞状细胞癌的淋巴结转移。
Abstract:
To explore the effect of neoadjuvant chemotherapy on the expressions of CCR7 and VEGFC in esophageal squamous cell carcinoma(ESCC) tissue.Methods:The expressions of CCR7 and VEGFC in 45 specimens of ESCC removed by operation only(operation only group) and 25 specimens removed by operation following the neoadjuvant chemotherapy(neoadjuvant chemotherapy group) using immunohistochemistry method.Results: The lymphatic metastasis rate, the rate of CCR7, VEGFC positive expression in neoadjuvant chemotherapy group were 24.0%(6/25),48.0%(12/25),20.0%(5/25), respectively, much lower than those of operation group, which were 55.6%(25/45),75.6%(34/45),68.9%(31/45), respectively(χ2 was 6.48,5.41,15.28,respectively,P<0.05).The expression of CCR7 in operation only group was positively correlated to that of VEGFC(rs=0.623,P<0.05).Conclusion: Neoadjuvant chemotherapy may downregulate the expressions of CCR7 and VEGFC in ESCC tissue, which potentially tend to reduce lymphatic metastasis.

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备注/Memo

备注/Memo:
#通讯作者,男,1964年生,博士,主任医师,研究方向:肿瘤内科
更新日期/Last Update: 2010-05-18