[1]张金盈△,厉菁,姚海木,等.冠心病患者血浆sOX40L、MIF水平与冠状动脉病变程度的关系*[J].郑州大学学报(医学版),2009,(04):742-743.
 ZHANG Jinying,LI Jing,YAO Haimu,et al.Relationship between plasma sOX40L,MIF level and the severity of coronary lesions in patients with coronary heart disease[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):742-743.
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冠心病患者血浆sOX40L、MIF水平与冠状动脉病变程度的关系*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
742-743
栏目:
论著
出版日期:
2009-07-01

文章信息/Info

Title:
Relationship between plasma sOX40L,MIF level and the severity of coronary lesions in patients with coronary heart disease
作者:
张金盈厉菁姚海木张力
郑州大学第一附属医院心内科 郑州 450052
Author(s):
ZHANG JinyingLI JingYAO HaimuZHANG Li
Department of Cardiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
冠心病急性冠脉综合征可溶性OX40配体巨噬细胞移动抑制因子
Keywords:
coronary heart disease acute coronary syndromesoluble OX40 ligendmigration inhibitory factor
分类号:
R541.4
摘要:
探讨冠心病患者血浆可溶性OX40配体(sOX40L)和巨噬细胞移动抑制因子(MIF)与冠状动脉病变程度的关系。方法:68例冠心病患者包括急性心肌梗死(AMI)14例,不稳定型心绞痛(UAP)37例,稳定型心绞痛(SAP)17例;行冠脉造影判定冠状动脉病变程度,单支病变26例,双支病变24例,三支病变18例。20例冠状动脉造影结果正常者为对照组。采用ELISA法测定血浆sOX40L和MIF水平。结果:4组sOX40L和MIF水平差异有统计学意义(F分别为2.82,3.05,P均<0.05)。AMI和UAP组血浆sOX40L和MIF水平高于SAP组和对照组(P<0.05),而SAP组与对照组之间差异无统计学意义(P>0.05)。不同冠脉病变程度组sOX40L和MIF水平差异有统计学意义(F分别为2.78,2.93,P均<0.05)。单支、双支、三支病变组血浆sOX40L和MIF水平均高于对照组 (P<0.05),但单支、双支与三支病变组间差异均无统计学意义(P>0.05)。AMI组、UAP组患者血浆sOX40L和MIF水平正相关(r分别为0.624,0.637,P均<0.05),SAP组、对照组患者sOX40L和MIF水平无相关性(P>0.05)。结论:血浆sOX40L和MIF可作为预测斑块稳定性的标志物,为冠心病危险分层及采取积极干预措施提供依据,但不能反映冠状动脉狭窄程度及范围。

参考文献/References:

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备注/Memo

备注/Memo:
*河南省杰出青年科学基金资助项目094100510017△男,1967年生,主任医师,教授,研究方向:心脏病的介入性诊断和治疗,Email:jyzhang@zzu.edu.cn
更新日期/Last Update: 2010-05-18