[1]王瑞,王瑞林,耿丽,等.胰岛素联合5氟尿嘧啶对H22肝癌移植瘤裸鼠的化疗增效作用*[J].郑州大学学报(医学版),2009,(04):763-765.
 WANG Rui,WANG Ruilin,GENG Li,et al.Enhancement of chemotherapeutic response of insulin on 5fluorouracil in nude mice with transplanted H22 liver cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):763-765.
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胰岛素联合5氟尿嘧啶对H22肝癌移植瘤裸鼠的化疗增效作用* ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
763-765
栏目:
论著
出版日期:
2009-07-01

文章信息/Info

Title:
Enhancement of chemotherapeutic response of insulin on 5fluorouracil in nude mice with transplanted H22 liver cancer
作者:
王瑞王瑞林耿丽王留兴樊青霞#
郑州大学第一附属医院肿瘤科 郑州 450052
Author(s):
WANG RuiWANG RuilinGENG LiWANG LiuxingFAN Qingxia
Department of Oncology,the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
胰岛素样生长因子1胰岛素增效H22肝癌裸鼠5氟尿嘧啶
Keywords:
insulinlike growth factor1 insulin enhancement H22 liver cancer nude mouse 5fluorouracil
分类号:
R735.7
摘要:
观察胰岛素能否增强5氟尿嘧啶(5FU)对裸鼠的化疗疗效,并探讨血清胰岛素样生长因子1(IGF1)水平在其增效机制中的意义。方法:60只裸鼠建立H22肝癌移植瘤模型后,随机分为6组,每组10只:对照组、单用大剂量胰岛素组、5FU组、大、中、小剂量胰岛素(4.5、3.0、1.5 U/kg)联合5FU组。5FU按10 mg/kg腹腔注射,每天用药1次,连用8 d。观察各组抑瘤率,并用ELISA方法检测裸鼠血清中IGF1和胰岛素样生长因子结合蛋白3(IGFBP3)含量。结果:4组肿瘤生长抑制率比较,差异有统计学意义(F=71.410,P<0.001),且大剂量胰岛素联合5FU组对H22肝癌移植肿瘤生长抑制率达(51.35±3.14)%,高于5FU组的(27.93±2.35)%(P<0.05)。4组血清IGF1水平比较,差异有统计学意义(F=13.720,P<0.001),且大剂量胰岛素联合5FU组血清IGF1水平[(492.13±58.88) μg/L]低于5FU组[(595.51±260.77) μg/L](P<0.05)。结论:在裸鼠H22肝癌移植瘤模型中,胰岛素能增强5FU化疗疗效,其增效机制可能与IGF1水平有关。

参考文献/References:

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备注/Memo

备注/Memo:
*河南省卫生厅科技创新人才基金资助项目2005026 #通讯作者,女,1952年生,大学本科,教授,研究方向:恶性肿瘤综合治疗
更新日期/Last Update: 2010-05-18