[1]张菊娥)△,郭茂峰),张贵星),等.肺癌患者全血自由基代谢及其酶类测定*[J].郑州大学学报(医学版),2009,(04):766-768.
 ZHANG Jue),GUO Maofeng),ZHANG Guixing),et al.Detection of free radical metabolism and its protective enzymes of lung carcinoma patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):766-768.
点击复制

肺癌患者全血自由基代谢及其酶类测定*()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
766-768
栏目:
论著
出版日期:
2009-07-01

文章信息/Info

Title:
Detection of free radical metabolism and its protective enzymes of lung carcinoma patients
作者:
张菊娥1)郭茂峰1)张贵星1)张翠英2)王留兴3)
1)郑州大学基础医学院生物化学与分子生物学教研室 郑州 4500012)郑州大学第五附属医院内科 郑州 4500523)郑州大学第一附属医院肿瘤科 郑州 450052
Author(s):
ZHANG Ju’e1)GUO Maofeng1)ZHANG Guixing1)ZHANG Cuiying2)WANG Liuxing3)
关键词:
肺癌超氧化物歧化酶谷胱甘肽过氧化物酶过氧化氢酶脂质过氧化物自由基
Keywords:
lung carcinomasuperoxide dismutaseglutathione peroxidasecatalaselipid peroxidefree radical
分类号:
R734.2;R34
摘要:
测定肺癌患者血过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSHPx)、超氧化物歧化酶(SOD)及其同工酶活性和脂质过氧化物(LPO)的水平。方法:采用生物化学方法测定肺癌患者(n=29)、肺良性疾病患者(n=30)和健康人(n=32)血CAT、GSHPx、SOD及其同工酶铜、锌超氧化物歧化酶(CuZnSOD)、锰超氧化物歧化酶(MnSOD)活性及LPO水平。结果:3组间GSHPx、SOD、CuZnSOD活性、LPO含量及LPO/GSHPx、LPO/SOD比值比较,差异均有统计学意义(F分别为11.61、3.90、6.30、61.26、151.40、17.74,P<0.05或0.01),CAT、MnSOD活性比较,差异无统计学意义(F分别为0.61、0.96,P均>0.05)。结论:肺癌的发病可能与GSHPx、SOD、CuZnSOD活性下降及LPO水平升高有关。
Abstract:
To detect the levels of catalase (CAT), glutathione peroxidase (GSHPx), superoxide dismutase (SOD), and lipid peroxide (LPO) in patients of lung carcinoma.Methods:The levels of CAT activity, GSHPx activity,SOD, CuZnSOD, and MnSOD activity in blood as well as LPO level in the patients with lung carcinoma(n=29),patients with benign lung diseases(n=30), and the health control(n=32) were detected by using biochemical analysis method.Results:There were significant differences among three groups on GSHPx,SOD,CuZnSOD activities,LPO level,LPO/GSHPx,and LPO/SOD(F=11.61,3.90,6.30,61.26,151.40,17.74,P<0.05 or 0.01).There were no significant differences among three groups on CAT and MnSOD activities(F=0.61,0.96,P>0.05).Conclusion: The lung carcinoma may be associated with decrease of GSHPx,SOD, and CuZnSOD activities and increase of LPO level.

参考文献/References:

[1]Lee GH,Matsushita H.Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice[J].Cancer Sci,2005,96(5):256
[2]戚其学,徐楠,吴哲.脑血管病急性期患者血清脂质过氧化物、谷胱甘肽过氧化物酶和超氧化物歧化酶的检测及其临床意义的研究[J].中国血液流变学杂志,2007,17(3):375
[3]Wang M,Devereux TR,Vikis HG,et al.Pol is a candidate for the mouse pulnonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia[J].Cancer Res,2004,64(6):1 924
[4]Rao GM,Rao AV,Raja A,et al.Role of antioxidant enzymes in brain tumours[J].Clin Chim Acta,2000,296(1/2):203
[5]荆洁线,张羽捷,韩存芝,等. 肺癌患者抗氧化体系损伤与细胞因子相关性研究[J].中国肿瘤临床与康复,2003,10(5):399
[6]田辉,李林,孙东峰,等.POL1基因与肺癌易感性的研究进展[J].中国老年学杂志,2007,27(6):590
[7]张付昌,闫凌云,杨雪辉,等.石棉对人血清超氧化物歧化酶活力及脂质化水平的研究[J].河南预防医学杂志,2007,18(4):252

相似文献/References:

[1]王玉珍,吴逸明,李伟辉,等.热休克蛋白70hom基因+2 437(T/C)位点基因多态性与肺癌的关系*[J].郑州大学学报(医学版),2010,(02):219.
 WANG Yuzhen,WU Yiming,LI Weihui,et al.Heat shock protein 70hom gene+2 437(T/C) polymorphism and susceptibility to lung cancer in Chinese Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):219.
[2]刘艳华),王玲),王彦平),等.膳食因素与肺癌关系的病例对照研究[J].郑州大学学报(医学版),2009,(06):1260.
 LIU Yanhua),WANG Ling),WANG Yanping),et al.A casecontrol study on relationship between dietary intake and relative factors and lung cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):1260.
[3]张菊娥)△,陈小让),张翠英),等.四君子汤加柴胡对长期摄酒小鼠血脂及抗氧化作用的影响[J].郑州大学学报(医学版),2009,(05):1045.
 ZHANG Jue),CHEN Xiaorang),ZHANG Cuiying),et al.Effect of Sijun decoction with bupleurum falcatum on blood lipid and its antioxidation ability in alcoholintake mice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):1045.
[4]马会军),李耀军),牛松涛),等.非小细胞肺癌40例介入治疗体会[J].郑州大学学报(医学版),2009,(05):1106.
[5]刘天舟,张琳,王庆芳,等.血清CEA、NSE、SCCAg和CYFRA211联合检测对肺癌诊断的价值[J].郑州大学学报(医学版),2010,(05):809.
 LIU Tianzhou),ZHANG Lin),WANG Qingfang),et al.Diagnostic value of combined determination of serum CEA,NSE,SCCAg and CYFRA211 for lung cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):809.
[6]齐宇)△,李鑫),杨鲲鹏),等.支气管肺泡灌洗液中CYFRA211、NSE和CEA联合检测对肺癌的诊断价值[J].郑州大学学报(医学版),2010,(04):618.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):618.
[7]杜晓光,吕栋,谢新立,等.原发性肺癌合并骨转移242例骨痛分析[J].郑州大学学报(医学版),2010,(04):670.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):670.
[8]张慧珍,张丰泉,王钧,等.微囊藻毒素LR对原代培养的大鼠睾丸支持细胞SOD活性及LDH漏出率的影响[J].郑州大学学报(医学版),2010,(06):1013.
[9]李立△,王亚东,张聪恪,等.大豆异黄酮复合胶囊对人体的抗氧化作用[J].郑州大学学报(医学版),2011,(03):457.
 LI Li,WANG Yadong,ZHANG Congke,et al. Effects of compound capsule of soy isoflavone on antioxidation of human body[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(04):457.
[10]黄月),张善锋),许予明)#,等. 6羟基多巴胺诱导帕金森病大鼠相关蛋白及mRNA的表达[J].郑州大学学报(医学版),2011,(02):222.
 HUAGN Yue,ZHANG Shanfeng,et al. Expression of related protein and mRNA in 6hydroxydopamineinduced Parkinson’s disease rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(04):222.

备注/Memo

备注/Memo:
*河南省卫生厅科技攻关基金资助项目90013 △女,1953年生,硕士,副教授,研究方向:肿瘤酶学,Email:Zje8866@zzu.edu.cn
更新日期/Last Update: 2010-05-18