[1]赵玉兰)△,海冰峰),王婷),等.卡维地洛对改善压力负荷大鼠心室肥厚的作用[J].郑州大学学报(医学版),2009,(04):784-785.
 ZHAO Yulan),HAI Bingfeng),WANG Ting),et al.Effect of carvedilol on ventricular hypertrophy in pressureoverloaded rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):784-785.
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卡维地洛对改善压力负荷大鼠心室肥厚的作用 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
784-785
栏目:
论著
出版日期:
2009-07-01

文章信息/Info

Title:
Effect of carvedilol on ventricular hypertrophy in pressureoverloaded rats
作者:
赵玉兰1)海冰峰1)王婷2)程劲松3)
1)郑州大学第二附属医院心内科 郑州 4500142)陕西省人民医院医教处 西安 7100683)北京协和医学院研究生院 北京 100730
Author(s):
ZHAO Yulan1)HAI Bingfeng1)WANG Ting2)CHENG Jinsong3)
关键词:
卡维地洛心室肥厚肿瘤坏死因子α基质金属蛋白酶2
Keywords:
carvedilolventricular hypertrophyTNFαMMP2
分类号:
R544.1
摘要:
观察β受体阻滞剂卡维地洛对压力负荷大鼠心室重构的影响。方法:27只雄性SD大鼠随机分为假手术组(A组)9只、心肌肥厚组(B组)9只和卡维地洛组(C组)9只,B、C组行腹主动脉缩窄术造成后负荷增高型大鼠模型。C组大鼠给予卡维地洛15 mg·kg-1·d-1灌胃,A组和B组给予等量蒸馏水灌胃。4周后检测血流动力学指标和心肌肥厚指数,采用放射免疫法测定血清TNFα水平,免疫组化法检测心室肌中MMP2和TIMP2的表达。结果:3组间比较,左室舒张末压、左室压力最大上升及下降速率、右室心肌肥厚指数差异无统计学意义(F分别为0.617,1.120,1.391和0.790,P均>0.05);心率、平均颈动脉压、左室收缩末压、左室心肌肥厚指数、血清TNFα水平及心室肌MMP2和TIMP2蛋白的表达差异有统计学意义(F分别为8.704,10.677,13.277,11.067,47.791,736.593和206.109,P均<0.05)。与A组比较,B组平均颈动脉压、左室收缩末压和左室心肌肥厚指数升高(P<0.05),血清TNFα水平升高(P<0.01),MMP2和TIMP2的表达增加(P<0.01);与B组比较,C组上述指标均有所降低(P<0.05)。结论:卡维地洛能减轻压力负荷大鼠的心室肥厚,下调过度表达的MMP2及升高的TNFα水平是其防治心室重构的机制之一。

参考文献/References:

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备注/Memo

备注/Memo:
△女,1956年生,主任医师,教授,研究方向:心力衰竭及其相关疾病
更新日期/Last Update: 2010-05-18