[1]赵春临),乔军波),张谢夫)#,等.胃癌组织中67LR和半乳糖凝集素3基因mRNA的表达[J].郑州大学学报(医学版),2009,(04):791-793.
 ZHAO Chunlin),QIAO Junbo),ZHANG Xiefu),et al.Detection of 67LR and galectin3 mRNA in gastric carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):791-793.
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胃癌组织中67LR和半乳糖凝集素3基因mRNA的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
791-793
栏目:
论著
出版日期:
2009-07-01

文章信息/Info

Title:
Detection of 67LR and galectin3 mRNA in gastric carcinoma tissue
作者:
赵春临1)乔军波2)张谢夫1)#高志军1)陈文超3)刘涛1)
1)郑州大学第一附属医院普外科;河南省高等学校临床医学重点学科开放实验室 郑州 4500522)河南省人民医院血管病外科 郑州 4500033)郑州大学第二附属医院急诊科 郑州 450014
Author(s):
ZHAO Chunlin1)QIAO Junbo2)ZHANG Xiefu1)GAO Zhijun1)CHEN Wenchao3)etc
关键词:
67LR 半乳糖凝集素3胃癌
Keywords:
67LR galectin3gastric carcinoma
分类号:
R735.2
摘要:
探讨67 000层黏连蛋白受体(67LR)mRNA和半乳糖凝集素3(galectin3) mRNA在胃癌组织中的表达及意义。方法:采用原位杂交方法检测78 例胃癌组织中67LR和galectin3 mRNA的表达情况。结果:胃癌组织中67LR、galectin3 mRNA阳性率分别为60.3%(47/78)、83.3%(65/78),高于正常胃黏膜组织中的20.0%(4/20)、25.0%(5/20)(χ2分别为10.336,26.592,P均<0.01)。胃癌组织中67LR、galectin3 mRNA的阳性表达与患者的年龄、性别、Lauren 分型无关(P均>0.05);67LR mRNA的表达与胃癌组织分化程度有关(χ2=7.770,P<0.05),而galectin3 mRNA的表达与胃癌组织分化程度无关(χ2=1.505,P>0.05);在有淋巴结转移的癌组织中2者表达均增高(χ2=7.595,11.440,P<0.01);随浸润深度的增加和PTNM分期的升高,2者表达均增强(67LR:χ2=11.153、12.747;galectin3:χ2=10.986、11.440,P均<0.01)。胃癌组织中67LR mRNA与galectin3 mRNA表达存在正相关(r=0.260,P<0.05)。结论:胃癌组织中67LR及galectin3的表达可能在基因转录水平已经上调,2个基因可能参与了胃癌的发生、发展,与胃癌的侵袭、转移密切相关。

参考文献/References:

[1]Colognato H,Yurchenco PD.Form and function:the laminin family of heterotrimers[J].Dev Dyn,2000,218(2):213
[2]Miyazaki J,Hokari R,Kato S,et al.Increased expression of galectin3 in primary gastric cancer and the metastatic lymph nodes[J].Oncol Rep, 2002,9(6):1 307
[3]GivantHorwitz V,Davidson B,van de Putte G,et al.Expression of the 67kDa laminin receptor and the alpha6 integrin subunit in serous ovarian carcinoma[J].Clin Exp Metastasis,2003,20(7):599
[4]Engbring JA, Kleinman HK.The basement membrane matrix in malignancy [J].J Pathol,2003,200(4):465
[5]Pupa SM,Me’nard S,Forti S,et al.New insights into the role of extracellular matrix during tumor onset and progression[J].J Cell Physiol,2002,192(3):259
[6]Berno V,Porrini D,Castiglioni F,et al.The 67 kDa laminin receptor increases tumor aggressiveness by remodelling laminin1[J].Endocr Relat Cancer,2005,12(2):393
[7]Shekhar MP, NangiaMakker P, Tait L,et al.Alterations in galectin3 expression and distribution correlate with breast cancer progression: functional analysis of galectin3 in breast epithelialendothelial interactions[J]. Am J Pathol,2004,165(6):1 931
[8]NangiaMakker P, Raz T, Tait L,et al.galectin3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancer[J]. Cancer Res,2007,67(24):11 760
[9]Shimura T,Takenaka Y,Fukumori T,et al.Implication of galectin3 in Wnt Signaling[J].Cancer Res,2005,65(9):3 535
[10]Yu LG,Andrews N,Zhao Q,et al.Galectin3 interaction with thomsenfriedenreich disaccharide on cancerassociated MUC1 causes increased cancer cell endothe1ial adhesion[J].J Biol Chem,2007,282(1):773
[11]Oka N,Nakahara S,Takenaka Y,et al.Galectin3 inhibits tumor necrosis factorrelated apoptosisinducing ligandinduced apoptosis by activating akt in human bladder carcinoma cells[J].Cancer Res,2005,65(17):7 546等

备注/Memo

备注/Memo:
#通讯作者,男,1957年生,教授,主任医师,研究方向:胃肠道肿瘤,Email:zhangxiefu@medmail.com.cn
更新日期/Last Update: 2010-05-18