[1]阚全娥△,文世林.初诊2型糖尿病视网膜病变患者颈动脉内膜中层厚度及微量白蛋白尿测定[J].郑州大学学报(医学版),2009,(04):842-843.
 KAN Quane,WEN Shilin.Detection of carotid artery intimamedia thickness and microalbuminuria of newly diagnosed type 2 diabetes mellitus patients with diabetic retinopathy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):842-843.
点击复制

初诊2型糖尿病视网膜病变患者颈动脉内膜中层厚度及微量白蛋白尿测定 ()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年04期
页码:
842-843
栏目:
论著
出版日期:
2009-07-01

文章信息/Info

Title:
Detection of carotid artery intimamedia thickness and microalbuminuria of newly diagnosed type 2 diabetes mellitus patients with diabetic retinopathy
作者:
阚全娥文世林
河南省人民医院内分泌科 郑州 450003
Author(s):
KAN Quan’eWEN Shilin
Department of Endocrinology, Henan Provincial Peoples Hospital,Zhengzhou 450003
关键词:
2型糖尿病糖尿病视网膜病变颈动脉内膜中层厚度微量白蛋白尿
Keywords:
type 2 diabetes mellitusdiabetic retinopathycarotid artery intimamedia thicknessmicroalbuminuria
分类号:
R587.1
摘要:
探讨初诊2型糖尿病患者视网膜病变(DR)与微量白蛋白尿(MA)、颈动脉内膜中层厚度(CAIMT)的关系。方法:筛选92例初诊2型糖尿病患者,根据眼底检查结果,分为DR组46例,无糖尿病视网膜病变(NDR)组46例,测定其MA和CAIMT,观察2组患者的空腹及餐后血糖、糖化血红蛋白、血脂(包括胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯)、血压及体质指数。结果:2组患者的年龄、体质指数、空腹血糖、餐后血糖及糖化血红蛋白水平差异无统计学意义(t分别为1.156,0.970,0.489,-0.489,-0.474及-0.242,P均>0.05);DR组的收缩压、舒张压、甘油三酯、低密度脂蛋白胆固醇水平高于NDR组(t=2.73,3.02,2.074和2.359,P均<0.05);DR组的MA和CAIMT高于NDR组(t=3.10和3.65,P<0.01)。结论:初发2型糖尿病DR与CAIMT、MA有关。
Abstract:
To explore the relationship between diabetic retinopathy(DR) in newly diagnosed type 2 diabetes mellitus and CAIMT, MA.Methods:A total of 92 patients with newly diagnosed type 2 diabetes mellitus were divided into two groups according to the examination of eyegroud,46 patients with DR(DR groups),46 patients without DR(NDR group).Albumin,CAIMT, FBG, PBG, HbAlc, CHO, LDLC, HDLC, TG, BMI and BP were mearsured and analyzed.Results: There was no difference in age, BMI ,FBG, PBG and HbAlc of the two groups (t was 1.156,0.970,0.489,-0.489,-0.474,and -0.242,P>0.05).The BP,TG and LDLC of DR group were higher than those of NDR group(t=2.73,3.02,2.074,and 2.359,P<0.05).The albumin and CAIMT of DR group were higher obviously than the NDR group(t=3.10 and 3.65,P<0.01).Conclusion:DR in newly diagnosed type 2 diabetes mellitus had significant correlation with CAIMT and MA.

参考文献/References:

[1]Juutilainen A,Lehto S,Ronnemaa T,et al. Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women[J]. Diabetes Care,2007,30(2):292
[2]van Hecke MV,Dekker JM,Stehouwer CD,et al. Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: the EURODIAB prospective complications study[J]. Diabetes Care ,2005,28(6):1 383
[3]Rema M,Mohan V,Deepa R,et al. Association of carotid intimamedia thickness and arterial stiffness with diabetic retinopathy: the Chennai Urban Rural Epidemiology Study (CURES2)[J]. Diabetes Care, 2004,27(8):1 962
[4]van Hecke MV,Dekker JM,Nijpels G,et al. Are retinal microvascular abnormalities associated with large artery endothelial dysfunction and intimamedia thickness? The Hoorn Study[J]. Clinical Sci(Lond), 2006,110(5):597
[5]Moreno PR,Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis[J]. J Am Coll Cardiol, 2004,44(12):2 293
[6]胡凯,栾洁,孙子林,等.糖尿病视网膜病变与尿微量白蛋白的关系[J].江苏医药,2006,32(7):604
[7]邓宏明,肖常青,潘海林,等.2型糖尿病视网膜病变的多因素分析及尿微量白蛋白排泄率的预报作用研究[J].临床内科杂志,2004,21(6):378
[8]Klein R,Marino EK,Kuller LH,et al. The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study[J]. Br J Ophthalmol,2002,86(1):84

相似文献/References:

[1]吕聪敏)△,那建华),田晨光).老年2型糖尿病无症状心肌缺血患者心电学分析[J].郑州大学学报(医学版),2010,(02):287.
 LV Congmin),NA Jianhua),TIAN Chenguang).Electrocardiology analysis in old silent myocardial ischemia patients with type 2 diabetes mellitus[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):287.
[2]曲蕴慧))△,陈奎生).盐酸吡格列酮对2型糖尿病患者微量蛋白尿的影响[J].郑州大学学报(医学版),2009,(06):1279.
[3].空腹血糖受损及2型糖尿病人群多代谢异常Logistic分析*[J].郑州大学学报(医学版),2009,(02):340.
 YOU Aiguo),YU Dahai),LU Jie),et al.Logistic analysis on multiple metabolic disorders in impaired fasting glucose and type 2 diabetes mellitus patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):340.
[4]余勤),汪丽),秦贵军)#,等.初发2型糖尿病122例谷氨酸脱羧酶抗体筛查[J].郑州大学学报(医学版),2009,(02):451.
[5]蒋钰△,李春明.2型糖尿病患者餐后高甘油三酯血症对早期动脉粥样硬化形成的影响[J].郑州大学学报(医学版),2009,(01):140.
 JIANG Yu,LI Chunming.Relationship between postprandial hypertriglyceridemia and early atherosclerosis in type 2 diabetic patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):140.
[6]阚全娥),秦贵军).2型糖尿病并糖尿病足38例临床分析[J].郑州大学学报(医学版),2009,(03):670.
[7]孙锦峰),梅苑),时宝庆),等. 某社区2型糖尿病患者低成本社区干预评价[J].郑州大学学报(医学版),2011,(03):482.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(04):482.
[8]赵焕焕),史云菊),裴迎新)#,等. 郑州市某医院2型糖尿病患者膳食多样化调查[J].郑州大学学报(医学版),2011,(03):492.
[9]赵景志),李琳琳),庞超),等.郑州地区2型糖尿病患者一级亲属遗传度分析*[J].郑州大学学报(医学版),2012,(02):185.
 ZHAO Jingzhi),LI Linlin),PANG Chao),et al.Analysis of heritability in the first degree relatives of type 2 diabetes mellitus patients from Zhengzhou[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(04):185.
[10]吴建),张东霞),李小芳)#.河南省公共卫生服务多项目县2型糖尿病健康管理服务实施效果*[J].郑州大学学报(医学版),2012,(03):318.
 WU Jian),ZHANG Dongxia),LI Xiaofang).Efficacy of health management services for patients with type Ⅱdiabetes in Henan province[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(04):318.

备注/Memo

备注/Memo:
△女,1974年生,硕士,主治医师,研究方向:糖尿病及其并发症的防治
更新日期/Last Update: 2010-05-18