[1]周云△.顺铂和5氟尿嘧啶联合替尼泊苷或依托泊甙治疗晚期胃癌疗效对比*[J].郑州大学学报(医学版),2009,(05):955-956.
　ZHOU Yun.Comparison of regimen VCF and ECF in treatment of advanced gastric cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(05):955-956.
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顺铂和5氟尿嘧啶联合替尼泊苷或依托泊甙治疗晚期胃癌疗效对比*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年05期
页码:
955-956
栏目:
应用研究
出版日期:
2009-09-01

文章信息/Info

Title:
Comparison of regimen VCF and ECF in treatment of advanced gastric cancer
作者:
周云△
河南省人民医院肿瘤科郑州450003
Author(s):
ZHOU Yun
Department of Oncology, Henan Provincial People’s Hospital,Zhengzhou 450003
关键词:
胃肿瘤; 顺铂; 5氟尿嘧啶; 替尼泊苷; 依托泊甙; 化疗
Keywords:
gastric neoplasm; CDDP; 5FU; VM26; etoposide; chemotherapy
分类号:
R730.53
摘要:
观察顺铂（CDDP）和5氟尿嘧啶（5FU）联合替尼泊苷（VM26）组成的VCF方案或联合依托泊甙（VP16）组成的ECF方案治疗胃癌的疗效。方法：102例晚期胃癌患者分为VCF方案治疗组（54例）和ECF方案治疗组（48例），比较2组的治疗有效率（RR）、中位总生存时间（mOS）和无进展生存时间（DFS）以及药物毒副作用。结果：VCF方案治疗组和ECF方案治疗组的RR分别为75.9%和54.2%（χ2=5.883，P=0.021），mOS分别为9.3和6.6个月（χ2=9.799,P=0.002）；DFS为5.9和4.3个月（χ2=13.230，P=0.001）。VCF方案治疗组患者的白细胞减少、血小板减少、贫血的发生率分别为87.0%，42.6%和40.7%，高于ECF方案治疗且（70.8%，18.8%和14.6%）（χ2=4.081，6.710，8.545,P<0.05）。而ECF方案治疗组脱发的发生率为56.3%，高于VCF的35.2%（χ2=4.554,P<0.05）。结论：VCF方案治疗胃癌明显优于ECF方案的疗效，但骨髓毒性大于ECF方案。
Abstract:
For the better treatment of advanced gastric cancer, the chemotherapy regimens of VCF (VM26+CDDP+5FU) and ECF (VP16 +CDDP+5FU) were used to explore their clinical therapeutic effect and application prospects.Methods:A total of 102 patients with advanced gastric cancer were divided into group 1 (54 cases) and group 2(48 cases). Study objectives included overall response rate(RR), median overall survival(mOS),diseasefree time(DFS) and side effects.Results: RR of VCF and ECF were 75.9% and 54.2% (χ2=5.883，P=0.021), respectively;mOS was 9.3 months and 6.6 months (χ2=9.799,P=0.002),DFS was 5.9 months and 4.3 months(χ2=13.230，P=0.001),respectively. The incidence of neutropenia,decrease in platelets,and anemia of VCF were 87.0%,42.6%,40.7%,higher than those (70.8%，18.8% and 14.6%) of ECF(χ2=4.081,6.710,8.545,P<0.05). And the incidence of alopecia of ECF was 56.3%,higher than that (35.2%) of VCF.Conclusion:It is shown that chemotherapy regimen of VCF has better effects for the treatment of gastric cancer than ECF. VCF may have important clinical value, which deserves further study and research.

参考文献/References:

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备注/Memo

备注/Memo:
*河南省科技攻关基金资助项目0424410087 △男，1959年生，硕士，教授，研究方向：肿瘤的基础与临床,Email:zhy1336@yahoo.com.cn
更新日期/Last Update: 2010-05-14