[1]周云△.替尼泊苷和5氟尿嘧啶联合奥沙利铂或顺铂治疗晚期胃癌疗效对比[J].郑州大学学报(医学版),2009,(05):957-959.
 ZHOU Yun.Comparison of regimen VOF and VCF in treatment of advanced gastric cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(05):957-959.
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替尼泊苷和5氟尿嘧啶联合奥沙利铂或顺铂治疗晚期胃癌疗效对比 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年05期
页码:
957-959
栏目:
应用研究
出版日期:
2009-09-01

文章信息/Info

Title:
Comparison of regimen VOF and VCF in treatment of advanced gastric cancer
作者:
周云
河南省人民医院肿瘤科郑州450003
Author(s):
ZHOU Yun
Department of Oncology,Henan Provincial People’s Hospital,Zhengzhou 450003
关键词:
胃肿瘤替尼泊苷奥沙利铂化疗
Keywords:
gastric neoplasmteniposideoxdiplatinchemotherapy
分类号:
R730.53
摘要:
观察替尼泊苷(Vm26)和5氟尿嘧啶(5FU)联合奥沙利铂(OXA)组成的VOF或联合顺铂(CDDP)组成的VCF方案治疗晚期胃癌的疗效。方法:73例晚期胃癌患者分为VOF方案治疗组(38例)和VCF方案治疗组(35例),比较2组间的治疗有效率(RR),中位总生存时间(mOS),无进展生存时间(DFS)及不良反应发生率。结果:VOF及VCF方案治疗组的RR分别为68.4%和62.8%(χ2=0.250,P>0.05),mOS分别为10.0和8.9个月(χ2=3.203,P>0.05),DFS为6.6和6.5个月(χ2=1.221,P>0.05)。VCF方案治疗组患者的白细胞减少,恶心呕吐和厌食的发生率分别为82.9%,77.1%和77.1%,高于VOF方案治疗组的55.3%,55.3%和52.6%(χ2=6.428,3.873,4.773,P<0.05),而VOF方案的末梢神经毒性发生率为57.9%,高于VCF方案的2.8%(χ2=25.574,P<0.05)。结论:VOF方案治疗胃癌近期有效率与VCF方案的疗效相当,但毒副反应小于后者。
Abstract:
To compare the effects and toxicity of chemotherapy regimens of VOF(VM26+LOHP+5FU),and VCF(VM26+CDDP+5FU).Methods:A total of 73 cases of advanced gastric cancer were allocated into,group 1 (38 cases) and group 2(35 cases).Study objectives included overall response rate(RR), median overall survival (mOS),disease free time(DFS) and side effects.Results: The effect of VOF for gastric cancer was similar with the effect of VCF,and the response rates were 68.4% and 62.8% (χ2=0.250,P>0.05),mOS was 10.0 months and 8.9 months(χ2=3.203,P>0.05),DFS was 6.6 months and 6.5 months(χ2=1.221,P>0.05), respectively. The incidence of neutropenia(82.9%),nausea and vomitting (77.1%) and decreased appetite(77.1%) of VCF were higber than those(55.3%,55.3% and 52.6%) of VOF(χ2=6.428,3.873,4.773,P<0.05), but the incidence of peripheral nerve toxicity of VOF was 57.9%,higher than that (2.8%)of VCF(χ2=25.574,P<0.05).Conclusion:It is shown that chemotherapy regimen of VOF and VCF have similar effects to treat gastric cancer, but VOF has less toxicity than VCF.

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备注/Memo

备注/Memo:
*河南省科技攻关基金资助项目0424410087△男,1959年生,硕士,教授,研究方向:肿瘤的基础与临床,Email:zhy1336@yahoo.com.cn
更新日期/Last Update: 2010-05-14