[1]孙翠萍)△,马建军)#,李学),等.无症状性脑梗死患者血清脂蛋白(α)水平与纤溶活性检测*[J].郑州大学学报(医学版),2009,(05):966-967.
 SUN Cuiping),MA Jianjun),LI Xue),et al.Detection of serum lipoprotein (α) level and fibrinolytic activity in patients with silent cerebral infarction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(05):966-967.
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无症状性脑梗死患者血清脂蛋白(α)水平与纤溶活性检测*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年05期
页码:
966-967
栏目:
论著
出版日期:
2009-09-01

文章信息/Info

Title:
Detection of serum lipoprotein (α) level and fibrinolytic activity in patients with silent cerebral infarction
作者:
孙翠萍1)马建军2)#李学2)冯艳2)袁丽品2)徐军2)
1)河南省肿瘤医院内科郑州4500082)河南省人民医院神经内科郑州450003
Author(s):
SUN Cuiping1) MA Jianjun2) LI Xue2) FENG Yan2) YUAN Lipin2) XU Jun2)
1)Department of Internal Medicine, Henan Provincial Tumor Hospital, Zhengzhou 4500082)Department of Neurology, Henan Provincial People’s Hospital, Zhengzhou 450003
关键词:
脑梗死脂蛋白(α)组织型纤溶酶原激活物纤溶酶原激活物抑制剂
Keywords:
cerebral infarction lipoprotein(α) tissuetype plasminogen activator plasminogen activator inhibitor
分类号:
R743.32
摘要:
探讨无症状性脑梗死(SCI)患者血清脂蛋白(α)[Lp(α)]水平与纤溶活性的关系。方法:采用OlimpusAU5400全自动生化分析仪测定53例SCI患者和55例健康者(对照组)血清Lp(α)水平,用发色底物法检测血浆组织型纤溶酶原激活物(tPA)和纤溶酶原激活物抑制剂(PAI)活性,并对SCI患者的血清Lp(α)水平与血浆tPA和PAI活性进行相关分析。结果:SCI组血清Lp(α)水平[(238.48±48.76)mg/L]高于对照组[(198.36±38.42)mg/L,t=4.759,P<0.05];SCI组tPA活性[(0.11±0.01)IU/mL]低于对照组[(0.49±0.12)IU/mL,t=-22.973,P<0.05],而PAI活性[(0.86±0.22)AU/mL]高于对照组[(0.48±0.10)AU/mL,t=11.626,P<0.05]。SCI组血清Lp(α)水平与tPA活性呈负相关(r=-0.676,P<0.05),与PAI活性呈正相关(r=0.813,P<0.05)。结论:血清Lp(α)水平升高是SCI重要的危险因素;其可能通过降低tPA的活性和(或)增强PAI的活性,干扰纤溶系统的平衡,参与SCI的形成。
Abstract:
To investigate the relationship between serum lipoprotein (α) [Lp (α)] and fibrinolytic activity in patients with silent cerebral infarction (SCI).Methods:The serum Lp(α) levels were measured by OlimpusAU 5400 automatic biochemistry analyzer in 53 patients with SCI and 55 healthy controls. The plasma tissuetype plasminogen activator (tPA) and plasminogen activator inhibitor (PAI) activities were determined by chrimogenic substrate method. The correlation analysis was also made between serum Lp (α) and plasma tPA and PAI in patients with SCI.Results: The serum Lp (α) level in SCI group[(238.48±48.76) mg/L] was significantly higher than that in the control group[(198.36±38.42) mg/L,t=4.759,P<0.05]. The activity of tPA in SCI group [(0.11±0.01) IU/mL] was obviously lower than that in the control group [(0.49±0.12) IU/mL,t=-22.973,P<0.05], while the activity of PAI in SCI group [(0.86±0.22) AU/mL] was significantly higher than that in the control group [(0.48±0.10) AU/mL,t=11.626,P<0.05]. The serum Lp (α) level was negatively related with the activity of tPA(r=-0.676,P<0.05), but with positively related the activity of PAI (r=0.813,P<0.05) in SCI group.Conclusion: The high level of serum Lp(α) is an important risk factor for SCI. Lp (α) interfers with the balance of fibrinolytic systems by lowering the tPA activity and (or) increasing the PAI activity,which may be involved in the process of SCI.

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备注/Memo

备注/Memo:
*河南省医学科技攻关计划项目(2006);郑州市科技攻关计划项目064SGYS332162 △女,1966年生,硕士,副主任医师,研究方向:肿瘤相关疾病及脑血管病 #通讯作者,男,1964年生,硕士,主任医师,教授,研究方向:脑血管病、神经免疫及退行性疾病的基础与临床,Email:majj.2602@163.com
更新日期/Last Update: 2010-05-14