[1]巴月)△,武伟华),任丽君),等.氟暴露人群雌激素受体RsaⅠ基因多态性及其与骨密度异常的关系*[J].郑州大学学报(医学版),2009,(05):971-973.
 BA Yue),WU Weihua),REN Lijun),et al.Estrogen receptor RsaⅠgene polymorphism and bone mineral density in population exposed to fluoride[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(05):971-973.
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氟暴露人群雌激素受体RsaⅠ基因多态性及其与骨密度异常的关系*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年05期
页码:
971-973
栏目:
论著
出版日期:
2009-09-01

文章信息/Info

Title:
Estrogen receptor RsaⅠgene polymorphism and bone mineral density in population exposed to fluoride
作者:
巴月1)武伟华1)任丽君2)银恭举3)李海霞1)王刚1)杨如璞2)程学敏1)张亚玮4)崔留欣1)
1)郑州大学公共卫生学院环境卫生学教研室郑州4500012)开封市疾病预防控制中心开封4750013)河南省疾病预防控制中心郑州4500034)耶鲁大学公共卫生学院纽黑文06520
Author(s):
BA Yue1) WU Weihua1) REN Lijun2) YIN Gongjv3)LI Haixia1)WANG Gang1) YANG Rupu1) CHENG Xuemin2) ZHANG Yawei4) CUI Liuxin1)
1)Department of Environmental Health,College of Public Health, Zhengzhou University, Zhengzhou 4500012)Kaifeng Center for Disease Control and Prevention, Kaifeng 4750013)Henan Provincial Center for Disease Control and Prevention,Zhengzhou 4500524)School o
关键词:
雌激素受体基因多态性骨密度
Keywords:
estrogen receptorgene polymorphismbone mineral densityfluoride
分类号:
R599;R394.6
摘要:
调查不同氟暴露水平地区人群中雌激素受体(ER)RsaⅠ基因的多态性分布,并了解其与高氟区人群骨密度异常的关系。方法:分别在高氟区(100例)与对照区(110例)选择观察人群;采用聚合酶链反应限制性片段长度多态性(PCRRFLP)方法检测ERRsaⅠ基因型;应用X线检查两地部分人群(高氟区49例,对照区25例)骨结构改变。结果:高氟区和对照区人群骨密度异常率分别为87.8%和44.0%,差异有统计学意义(χ2=16.069,P<0.05);骨密度异常人群ERRsaⅠ基因型分布rr为66.7%,Rr为25.9%,RR为7.4%;骨密度正常人群分布rr为80.0%,Rr为10.0%,RR为10.0%,2类人群基因型分布比较差异无统计学意义(χ2=3.078,P>0.05);未发现携带纯和突变型RR的人群骨密度异常的危险性增高(OR=0.56,95%CI:0.09~3.56)。结论:ERRsaⅠ基因多态性与高氟暴露人群骨密度异常无明显关系。
Abstract:
To investigate the distribution of estrogen receptor(ER) RsaⅠgenotype in population exposed to high fluoride and to evaluate the relationship between ER RsaⅠgene polymorphism and bone mineral density.Methods:Polymerase chain reactionrestriction fragment length polymorphism analysis was used to determine ER RsaⅠgenotype in population who lived in the areas with or without high fluoride in drinking water. The change of bone mineral density was measured by dualenergy Xray absorptiometry.Results:Prevalence of abnormal bone mineral density was 87.8% and 44.0% in high fluoride area and control area respectively. There was a significant difference between the two groups (χ2 =16.069, P<0.05). The frequency of ER RsaⅠ genotype was rr 66.7%,Rr 25.9% and RR 7.4% in population with abnormal bone mineral density; rr 80.0 %,Rr 10.0% and RR 10.0% in population with normal bone mineral density. There was no significant difference between the two groups (χ2 =3.078,P>0.05). The risk (OR=0.56, 95%CI:0.09~3.56) was not elevated when carrying the homozygous genotype RR in the population with abnormal bone mineral density compared to population with normal bone mineral density.Conclusion: There was no association between polymorphisms in the ER gene with abnormal bone mineral density in high fluoride exposed populations.

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备注/Memo

备注/Memo:
*河南省医学科技攻关基金资助项目20060374;河南省教育厅自然科学基金资助项目2009A330005 △女,1963年生,博士,副教授,研究方向:环境相关疾病的人群易感性,Email:bayue1963@hotmail.com
更新日期/Last Update: 2010-05-14