[1]杨利霞)△,骈林萍),李超).肝细胞癌多普勒超声影像与微血管密度、血管内皮生长因子表达的相关性分析[J].郑州大学学报(医学版),2009,(05):1006-1008.
　YANG Lixia),PIAN Linping),LI Chao).Relationship between tumoral vascularity with Doppler sonography，MVD and expression of VEGF in primary hepatocarcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(05):1006-1008.
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肝细胞癌多普勒超声影像与微血管密度、血管内皮生长因子表达的相关性分析 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年05期
页码:
1006-1008
栏目:
论著
出版日期:
2009-09-01

文章信息/Info

Title:
Relationship between tumoral vascularity with Doppler sonography，MVD and expression of VEGF in primary hepatocarcinoma
作者:
杨利霞1)△; 骈林萍2); 李超2)
1）郑州大学第二附属医院超声科郑州4500142）河南中医学院第一附属医院超声科郑州450000
Author(s):
YANG Lixia1); PIAN Linping2); LI Chao2)
1)Department of Ultrasound,the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014 2)Department of Ultrasound,the First Affiliated Hospital, Henan University of Traditional Chinese Medicine,Zhengzhou 450000
关键词:
肝细胞癌; 多普勒超声; 微血管密度; 血管内皮生长因子
Keywords:
hepatocellular carcinoma; color Doppler imaging; microvessel density; vascular endothelial growth factor
分类号:
R735.7
摘要:
探讨肝细胞癌的多普勒血流特点与微血管密度（MVD）及血管内皮生长因子（VEGF）的相关性。方法：采用多普勒超声记录32例肝细胞癌患者肝脏肿块的大小和血流分级，并测定血流阻力指数（RI）。取术后或穿刺的肿瘤组织进行MVD及VEGF免疫组化检测。结果：随血流分级的增高，MVD的表达逐渐增多（F=20.425,P<0.05），不同血流分级的VEGF阳性率间差异无统计学意义（χ2=0.793,P>0.05）。MVD、RI随肿块的增大而增高（F值分别为22.443和11.983，P均<0.05），RI与MVD呈正相关(r=0.812,P<0.05）。不同大小肿块间VEGF阳性率差异无统计学意义（χ2=0.154,P>0.05）。VEGF表达阳性组与VEGF表达阴性组之间MVD、RI值差异有统计学意义（t值分别为－3.056和－2.961，P均<0.05）。结论：多普勒超声是一种无创评价肝细胞癌血管生成活性的方法，可以为临床各种治疗和预后判定提供客观依据。
Abstract:
To investigate the relationship between intratumural blood flow assessed by color Doppler(CD) and microvessel density（MVD）,the expression of vascular endothelial growth factor(VEGF) in hepatocellular carcinoma.Methods:The intratumoral blood flow signal of hepatic carcinomas were performed with CD preoperatively and the resistance index(RI) was used for analysis. MVD and the expression of VEGF of excised tumor were assessed immunhistochemically.Results: A significant correlation was found between the blood flow grading and MVD(F=20.425,P<0.05).MVD and RI increased with the enlargement of tumor(F=22.443,11.983，P<0.05). There was a positive correlation between RI and MVD(r=0.812, P<0.05）. There were significant differences in RI and MVD in tumors with positive expression of VEGF compared with tumors with negative expression of VEGF(t=－3.056,－2.961,P<0.05).Conclusion: CD of HCC can be used as a noninvasive method to evaluate the angiogenesis activity of hepatic carcinoma and can provide an objective evidence for the treatment and assessment of prognosis.

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备注/Memo

备注/Memo:
△女，1952年生，大学本科，主任医师，研究方向：腹部疾病的超声诊断，Email：ylixia@263.net
更新日期/Last Update: 2010-05-14