[1]毛兰萍△,尚君兰,祝磊,等.人口腔扁平苔藓及口腔鳞癌组织中P16、Survivin蛋白的表达[J].郑州大学学报(医学版),2009,(05):1014-1015.
 MAO Lanping,SHANG Junlan,ZHU Lei,et al.Expression of P16 and Survivin protein in oral lichen planus and oral squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(05):1014-1015.
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人口腔扁平苔藓及口腔鳞癌组织中P16、Survivin蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年05期
页码:
1014-1015
栏目:
论著
出版日期:
2009-09-01

文章信息/Info

Title:
Expression of P16 and Survivin protein in oral lichen planus and oral squamous cell carcinoma tissue
作者:
毛兰萍尚君兰祝磊刘沛刘晓锦石爱梅#
郑州大学第一附属医院口腔科郑州450052
Author(s):
MAO Lanping SHANG Junlan ZHU Lei LIU Pei LIU Xiaojin SHI Aimei
Department of Stomatology,the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
P16Survivin口腔扁平苔藓口腔鳞状细胞癌
Keywords:
P16Survivinoral lichen planusoral squamous cell carcinoma
分类号:
R739
摘要:
探讨正常口腔黏膜组织、口腔扁平苔藓(OLP)、口腔鳞状细胞癌(OSCC)组织中P16、Survivin蛋白的表达情况及其临床意义。方法:采用免疫组化SP法检测26例正常口腔黏膜组织、40例糜烂型OLP组织及40例OSCC组织中P16、Survivin蛋白的表达情况,并分析其相关性。结果:正常口腔黏膜组织中P16蛋白阳性表达22例(84.6%),糜烂型OLP组织中P16蛋白阳性表达21例(52.5%),OSCC组织中P16蛋白阳性表达9例(22.5%),3组间比较差异有统计学意义(χ2=48.36,P<0.05)。正常口腔黏膜组织中Survivin蛋白阳性表达1例(3.9%),糜烂型OLP组织中Survivin蛋白阳性表达12例(30.0%),OSCC组织中Survivin蛋白阳性表达22例(55.0%),3组间比较差异有统计学意义(χ2=26.46,P<0.05)。结论:P16、Survivin蛋白在OSCC的发生发展中起重要作用
Abstract:
To study the expression and clinical significance of P16 and Survivin protein in oral lichen planus(OLP) and oral squamous cell carcinoma(OSCC) tissue.Methods:Immunohistochemical technique SP was used to detect the expression of P16 and Survivin protein in 40 cases of OSCC, 40 cases of OLP tissues and 26 cases of normal oral mucosa, and their clinical significance was also analyzed.Results: The results showed that P16 in 9 cases of OSCC tissues(22.5%), in 21 cases of OLP tissues(52.5%), and in 22 cases of normal oral mucosa (84.6%) had positive expression,and Survivin in 22 cases of OSCC tissues (55.0%),in 12 cases of OLP tissues (30.0%), and in 1 case of normal oral mucosa (3.9%) had positive expression.The expressions of P16 and Survivin were significantly different in normal oral mucosa, OLP and OSCC tissues (χ2=48.36,26.46,P<0.05).Conclusion: P16 and Survivin may play an important role in the occurrence and development of OSCC.

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备注/Memo

备注/Memo:
△女,1968年生,硕士,主治医师,研究方向:口腔黏膜病,Email:whryq123@163.com #通讯作者,女,1940年生,教授,主任医师,研究方向:口腔黏膜病
更新日期/Last Update: 2010-05-14