[1]刁云辉,张建立,冯百岁#.幽门螺杆菌感染患者胃黏膜组织中TLR2、TLR5的表达[J].郑州大学学报(医学版),2009,(05):1037-103.
 DIAO Yunhui,ZHANG Jianli,FENG Baisui.Expression of TLR2 and TLR5 in HPinfected gastric mucosa tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(05):1037-103.
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幽门螺杆菌感染患者胃黏膜组织中TLR2、TLR5的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年05期
页码:
1037-103
栏目:
论著
出版日期:
2009-09-01

文章信息/Info

Title:
Expression of TLR2 and TLR5 in HPinfected gastric mucosa tissue
作者:
刁云辉张建立冯百岁#
郑州大学第一附属医院消化内科;河南省高等学校临床医学重点学科开放实验室郑州450052
Author(s):
DIAO YunhuiZHANG JianliFENG Baisui
Department of Gastroenterology, the First Affiliated Hospital,Zhengzhou University; Institute Clinical Medical Research of Universities Henan,Zhengzhou 450052
关键词:
幽门螺杆菌Toll样受体
Keywords:
H. pylori Tolllike receptor
分类号:
R573
摘要:
检测幽门螺杆菌(HP)感染患者胃黏膜组织中Toll样受体TLR2、TLR5的表达。方法:采用免疫组化SP法检测33例非HP感染患者(对照组)和35例HP感染患者(试验组)胃黏膜组织中TLR2和TLR5的表达。结果:TLR2在试验组和对照组均无表达。试验组胃黏膜组织中TLR5的阳性表达率(60.0%)明显低于对照组(84.8%)(χ2=5.209,P<0.05)。结论:TLR2在人胃黏膜组织中无表达,HP感染可下调胃黏膜组织中TLR5的表达。
Abstract:
To investigate the expression of TLR2 and TLR5 in HP infected gastric mucosa.Methods:Immunohistochemistry SP method was adopted to detect the expressions of TLR2 and TLR5 in gastric mucosa from 33 controls (control group)and 35 cases of gastric mucosa with HP infection(trial group),respectively.Results:The expression of TLR2 in both groups was not detected.In trial group and control group, the positive expression rate of TLR5 was 60.0% and 84.8%,respectively,and the difference between the two groups was significant(χ2=5.209,P<0.05).Conclusion:TLR2 does not express in gastric mucosa in vivo.HP infection can downregulate the expression of TLR5 in gastric mucosa in vivo.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1965年生,博士,教授,研究方向:炎症性肠病的基础与临床研究,Email:fengbs@gmail.com
更新日期/Last Update: 2010-05-14