[1]陈妍琼),赵志华),张蕾)#,等.食管鳞状细胞癌组织中KiSS1蛋白和微血管密度的检测*[J].郑州大学学报(医学版),2009,(06):1127-1129.
 CHEN Yanqiong),ZHAO Zhihua),ZHANG Lei),et al.Expressions of KiSS1 protein and detection of MVD in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(06):1127-1129.
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食管鳞状细胞癌组织中KiSS1蛋白和微血管密度的检测*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年06期
页码:
1127-1129
栏目:
食管癌研究
出版日期:
2009-11-01

文章信息/Info

Title:
Expressions of KiSS1 protein and detection of MVD in esophageal squamous cell carcinoma tissue
作者:
陈妍琼1)赵志华2)张蕾1)# 高冬玲2)张岚2)陈奎生2)
1)郑州大学第一附属医院肿瘤科 郑州 4500522)郑州大学第一附属医院病理科;河南省肿瘤病理重点实验室 郑州 450052
Author(s):
CHEN Yanqiong1)ZHAO Zhihua2)ZHANG Lei1)GAO Dongling2)ZHANG Lan2)CHEN Kuisheng2)
1)Department of Oncology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2) Department of Pathology, the First Affiliated Hospital, Zhengzhou University;Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052
关键词:
食管肿瘤鳞状细胞癌KiSS1浸润转移微血管密度
Keywords:
esophageal neoplasmsquamous cell carcinomaKiSS1infiltrationmetastasismicrovessel density
分类号:
R735.1
摘要:
检测食管鳞状细胞癌组织中KiSS1蛋白和微血管密度(MVD)的表达。方法:应用免疫组化SP法分别检测 62例食管鳞状细胞癌[其中男36例,女26例,年龄38~75(60. 6±9.5)岁;组织学Ⅰ级15例,Ⅱ级25例,Ⅲ级22例; 7例肿瘤浸润黏膜层、黏膜下层或浅肌层,55例肿瘤浸润深肌层或外膜层;有淋巴结转移20例,无淋巴结转移42例]及 62例正常食管黏膜组织中KiSS1蛋白和MVD的表达,并探讨它们与食管鳞状细胞癌患者临床病理参数的关系。结果:食管鳞状细胞癌及正常食管黏膜组织中KiSS1蛋白的阳性表达率分别为56.5%(35/62)和90.3%(56/62),2者共阳性表达率为50.0%(31/62),差异有统计学意义(χ2=13.793,P<0.001);食管鳞状细胞癌组织中KiSS1蛋白的阳性表达率与患者的性别、年龄及组织学分级无关(χ2分别为0.471,0.104和1.011,P均>0.05),而与浸润深度及淋巴结转移有关(χ2分别为4.254和5.526,P均<0.05)。食管鳞状细胞癌组织中的MVD与患者的性别和年龄无关(t值分别为1.942和0.239,P均>0.05),而与肿瘤的组织学分级、浸润深度及淋巴结转移有关 (F=9.619,t值分别为-3.525和11.904,P均<0.05)。结论:KiSS1和MVD在食管鳞状细胞癌的浸润、转移中起重要作用,2者联合检测可判定食管鳞状细胞癌的侵袭和转移能力。
Abstract:
To detect the expressione of KiSS1 protein and microvessel density (MVD) in esophageal squamous cell carcinoma(ESCC).Methods:Immunohistochemical SP method was used to detect the expression of KiSS1 protein in 62 cases of ESCC, and 62 cases of normal esophageal epithelium tissues.MVD in 62 patients with ESCC and 62 case of normal esophageal epithelium tissue were detected by immunohistochemical SP method.Results: The positive expression rates of KiSS1 protein in ESCC and normal esophageal epithelium tissue were 56.5% and 90.3%,respectively(χ2=13.793,P<0.001). The low expression rate of KiSS1 protein in ESCC tissues was closely associated with the tumor invasive depth and lymphatic metastasis(χ2=5.526,4.254,P<0.05),but not with sex,age or histological grade(χ2=0.471,0.104,and 1.011,P>0.05) . MVD in patients with ESCC was significantly associated with the tumor differential degree,tumor invasive depth and lymph node metastasis(F=9.619,t=-3.525,11.904 ,P<0.05),but not with age or sex(t=0.239,1.942,P>0.05).Conclusion: KiSS1 and MVD play an important role in the infiltration and metastasis of ESCC. United examining KiSS1 and MVD will be one of the molecular indexes in the early diagnosis and prognosis of ESCC.

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备注/Memo

备注/Memo:
*河南省高校杰出科研人才创新工程基金资助项目2007KYCX005 #通讯作者,女,1968年生,博士,副教授,副主任医师,研究方向:消化道肿瘤,Email:zhanglei68616@yahoo.com.cn
更新日期/Last Update: 2010-05-14