[1]石磊),许予明),王五洲),等.河南汉族人群血小板膜糖蛋白Ⅰbα基因Kozak序列多态性与缺血性脑血管病的关联性*[J].郑州大学学报(医学版),2009,(06):1151-1152.
 SHI Lei),XU Yuming),WANG Wuzhou),et al.Association between Kozak sequence polymorphism of plantelet membrane glycoproteinⅠbα gene and ischemic cerebrovascular disorder in Henan Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(06):1151-1152.
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河南汉族人群血小板膜糖蛋白Ⅰbα基因Kozak序列多态性与缺血性脑血管病的关联性*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年06期
页码:
1151-1152
栏目:
论著
出版日期:
2009-11-01

文章信息/Info

Title:
Association between Kozak sequence polymorphism of plantelet membrane glycoproteinⅠbα gene and ischemic cerebrovascular disorder in Henan Han population
作者:
石磊1)许予明1)王五洲2)宋波1)王海珍1)杜冉1)张华3)郑红3)#
1)郑州大学第一附属医院神经内科 郑州 4500522)林州市人民医院神经内科 林州 4560003)郑州大学基础医学院细胞生物学与医学遗传学教研室 郑州 450001
Author(s):
SHI Lei1)XU Yuming1)WANG Wuzhou2)SONG Bo1)WANG Haizhen1)DU Ran1)ZHANG Hua3)ZHENG Hong3)
1)Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Neurology, People’s Hospital of Linzhou, Linzhou 4560003)Department of Cell Biology and Medical Genetics, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001
关键词:
血小板膜糖蛋白Kozak序列缺血性脑血管病基因多态性
Keywords:
plantelet membrane glycoproteinKozak sequenceischemic cerebrovascular disorderpolymorphism
分类号:
R394
摘要:
探讨河南地区汉族人群血小板膜糖蛋白(GP)Ⅰbα Kozak序列基因多态性与缺血性脑血管病的关联性。方法:采用PCRRFLP方法对缺血性脑血管病组(228例)和健康对照组(235例)进行Kozak序列多态性分析。结果:缺血性脑血管病组CC基因型频率为8.8%,C等位基因频率为29.2%,均高于对照组的4.3%和23.2%(χ2=3.896,P=0.048;χ2=4.281,P=0.039)。结论:GPⅠbα基因Kozak序列多态性可能与河南汉族人群缺血性脑血管病的发生相关。
Abstract:
To research the association between the Kozak sequence polymorphism of plantelet membrane glycoprotein(GP) Ⅰbα and ischemic cerebrovascular disorder in Henan Han population.Methods:The polymorphism of GPⅠbα Kozak gene5T/C in 228 cerebrovascular disorder patients and 235 normal control were detected with PCRRFLP.Results: The frequencies of CC genotype (8.8%) and C allele (29.2%) in cerebrovascular disorder group were higher than those in the control group(4.3% and 23.2%)(χ2=3.896,P=0.048;χ2=4.281,P=0.039).Conclusion: There may be an association between Kozak sequence polymorphism of GP receptorⅠbα and ischemic cerebrovascular disorder in Henan Han population.

参考文献/References:

[1]AfsharKharghan V,Li CQ,KhoshnevisAsl M,et al.Kozak sequence polymorphism of the glycoprotein (OP)Ⅰb alpha gene is a major determinant of the plasma membrane levels of the platelet GPⅠbⅨⅤcomplex[J].Blood,1999,94(1):186
[2]Douglas H,Michaelides K,Gorog DA, et al.Platelet membrane glycoproleinⅠb α gene5T/C Kozak sequence polymorphism as an independent risk factor for the occurrence of coronary thrombosis[J].Heart,2002,87(1):70
[3]Kozak M.Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryolie ribosomes[J].Cell,1986,44(2):283
[4]Baker RI, Eikelboom J,Lofrhouse E,et al.Platelet glycoproteinⅠbα Kozak polymorphism is associated with an increased risk of ischemic stroke[J].Blood,2001,98(1):36
[5]Cadroy Y,Sakariassen KS,Chadet JP,et al.Role of 4 platelet membrane glycoprotein polymorphisms on experimental arterial thrombus formation in men[J].Blood,2001,98(10):3 159
[6]Hsieh K,Funk M,Schillinger M,et al.Vienna stroke registry.Impact of the platelet glycoprotein Ⅰb alpha Kozak polymorphism on the risk of ischemic cerebrovascular events:a casecontrol study[J].Blood Coagul Fibrinolysisd,2004,15(6):469
[7]吕明恩,汪家敏,白霞,等.脑梗死患者血小板糖蛋白Ⅰbakozak序列多态性研究[J].江苏医药,2003,29(10):781
[8]Frank MB,Reiner AP,Schwartz SM,et al.The Kozak sequence polymorphism of platelet glycoprotein Ⅰbα and risk of nonfatal myocardial infarction and nonfatal stroke in young women[J].Blood,2001,97(4):875

相似文献/References:

[1]尚迎辉),李涛),白峻瑜),等.河南汉族动脉硬化性脑梗死人群血小板膜糖蛋白HPA2基因多态性检测*[J].郑州大学学报(医学版),2012,(05):605.
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备注/Memo

备注/Memo:
*河南省高校杰出人才创新工程基金资助项目2005KYCX02;河南省杰出青年科学基金资助项目0612001300;河南省卫生厅科技攻关基金资助项目200703005 #通讯作者,女,1963年生,博士,教授,研究方向:遗传性疾病致病基因的筛查与诊断,Email:hzheng@zzu.edu.cn
更新日期/Last Update: 2010-05-14