[1]赵春临),陈文超),张谢夫)#,等.胃肠道间质瘤组织中Livin、Ki67和MMP9的表达及生存分析[J].郑州大学学报(医学版),2009,(06):1232-1234.
 ZHAO Chunlin),CHEN Wenchao),ZHANG Xiefu),et al.Relationship between expression of Livin, Ki67 and MMP9 in gastrointestinal stromal tumor tissue and its prognosis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(06):1232-1234.
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胃肠道间质瘤组织中Livin、Ki67和MMP9的表达及生存分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年06期
页码:
1232-1234
栏目:
论著
出版日期:
2009-11-01

文章信息/Info

Title:
Relationship between expression of Livin, Ki67 and MMP9 in gastrointestinal stromal tumor tissue and its prognosis
作者:
赵春临1)陈文超2)张谢夫1)#刘涛1)
1)郑州大学第一附属医院普外科 郑州 4500522)郑州大学第二附属医院急诊科 郑州 450014
Author(s):
ZHAO Chunlin1) CHEN Wenchao2) ZHANG Xiefu1) LIU Tao1)
1)Department of General Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Emergency, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
胃肠道间质瘤LivinKi67基质金属蛋白酶9
Keywords:
gastrointestinal stromal tumorLivinKi67metrix metalloproteinases9
分类号:
R735.2
摘要:
探讨Livin、Ki67和基质金属蛋白酶9(MMP9)在胃肠道间质瘤组织中的表达及其在预后中的意义。方法:应用免疫组织化学SP法检测58例胃肠道间质瘤组织中Livin、Ki67和MMP9的表达。采用KaplanMeier进行单因素生存分析。结果:肿瘤大小、核分裂数、肿瘤原发部位、Livin表达、Ki67增殖指数及MMP9表达与患者的生存率有关(χ2分别为10.04、31.95、14.36、8.40、17.33和6.14,P均<0.05)。结论:Livin表达、Ki67增殖指数及MMP9表达在胃肠道间质瘤预后的估计方面具有应用价值。
Abstract:
To investigate the prognostic significance and expression of Livin, metrix metalloproteinases9(MMP9) and Ki67 in gastrointestinal stromal tumors (GISTs).Methods:SP method of immunohistochemistry was used to detect the expression of Livin, MMP9 and Ki67 expression in 58 cases of GISTs.Univariate survival analysis was used.Results:The tumor size, mitotic count, the primary location of tumor, the positive expression of Livin and MMP9, and the proliferation index of Ki67 were associated with survival (χ2 was 10.04,31.95,14.36,8.40,17.33,and 6.14,P<0.05).Conclusion: It is vital to examine the positive expression of Livin and MMP9 and the proliferation index of Ki67 when evaluating the prognosis of GISTs.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1957年生,大学本科,教授,研究方向:胃肠道肿瘤临床与基础,Email:zhangxiefu@medmail.com.cn
更新日期/Last Update: 2010-05-14