[1]刘月玲),李留霞)#,文建国),等.妊娠期高血压疾病患者胎盘、胎膜及腹膜组织中水通道蛋白3的表达[J].郑州大学学报(医学版),2009,(06):1268-1270.
 LIU Yueling),LI Liuxia),WEN Jianguo),et al.Expression of aquaporin 3 in placenta, membranes,and peritoneum of patients with hypertensive disorder complicating pregnancy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(06):1268-1270.
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妊娠期高血压疾病患者胎盘、胎膜及腹膜组织中水通道蛋白3的表达 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2009年06期
页码:
1268-1270
栏目:
论著
出版日期:
2009-11-01

文章信息/Info

Title:
Expression of aquaporin 3 in placenta, membranes,and peritoneum of patients with hypertensive disorder complicating pregnancy
作者:
刘月玲1)李留霞2)#文建国3)李真珍3)赵艳萍2)
1)安阳肿瘤医院妇科 安阳 4550002)郑州大学第一附属医院妇产科 郑州 4500523)郑州大学第一附属医院尿动力学中心;河南省高等学校临床医学重点学科开放实验室 郑州 450052
Author(s):
LIU Yueling1) LI Liuxia2) WEN Jianguo3) LI Zhenzhen3) ZHAO Yanping2)
1)Department of Genecology,Anyang Tumor Hospital,Anyang 4550002)Department of Obstetrics and Gynecology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500523)Department of Urodynamic Center,the First Affilated Hospital,Zhengzhou University;Henan Key Disciplines Open Laboratory of Clinical Medicine, Zhengzhou 450052
关键词:
妊娠期高血压疾病 水通道蛋白3 胎盘 胎膜腹膜
Keywords:
hypertensive disorder complicating pregnancyaquaporin 3placentamembraneperitoneum
分类号:
R714.24
摘要:
检测妊娠期高血压疾病患者胎盘、胎膜及腹膜组织中水通道蛋白3(AQP3)的表达。方法:采用免疫组织化学法检测60例妊娠期高血压疾病患者(包括妊娠期高血压20例,轻度子痫前期20例,重度子痫前期20例)及20例正常孕妇(正常妊娠组)胎盘、胎膜及腹膜组织中AQP3的表达。结果:4组孕妇胎盘、胎膜及腹膜组织中均有AQP3表达,分别位于胎盘组织合体滋养细胞及胎膜组织羊膜上皮细胞、腹膜组织间皮细胞上。重度子痫前期患者胎盘和腹膜中AQP3的表达较妊娠期高血压患者和正常孕妇强,胎膜中AQP3的表达较妊娠期高血压患者和正常孕妇弱,差异均有统计学意义(H=23.916、22.829及22.627,P均<0.05)。结论:AQP3可能与妊娠期高血压疾病的发生发展有关。
Abstract:
To detect the expression of aquaporin 3(AQP3) in placenta, membranes,and peritoneum in patients with hypertensive disorder complicating pregnancy(HDCP).Methods:Placenta,membranes,and peritoneum from 20 healthy women(healthy pregnancy group) and 60 cases of HDCP patients including 20 cases of gestational hypertension,20 cases of mild preeclampsia and 20 cases of severe preeclampsia.The expression of AQP3 was detected by immunohistochemistry.Results:AQP3 expression in placenta and peritoneum in severe preeclampsia group was stronger than those of gestational hypertension and healthy pregnancy group(P<0.05),while AQP3 expression in membranes in severe preeclampsia was milder than those of gestational hypertension and healthy pregnancy group (H=23.916,22.829,22.627,P<0.05).Conclusion:AQP3 may play an important role in the pathogenesis and devebopmen of HDCP.

参考文献/References:

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[1]李留霞△,石巍,乔玉环,等.妊娠期高血压孕妇胎盘组织中神经激肽B、胎盘生长因子的表达[J].郑州大学学报(医学版),2009,(03):554.
 LI Liuxia,SHI Wei,QIAO Yuhuan,et al.Expression and significance of neurokinin B and placenta growth factor in placentas with hypertensive disorder complicating pregnancy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(06):554.

备注/Memo

备注/Memo:
#通讯作者,女,1962年生,教授,主任医师,研究方向:妇科肿瘤、妊娠期高血压疾病的防治
更新日期/Last Update: 2010-05-14