[1]曾宪旭△,王玉萍,楚天骄,等.乳腺导管浸润癌组织中促肝细胞再生磷酸酶蛋白的表达*[J].郑州大学学报(医学版),2010,(01):57-58.
 ZENG Xianxu,WANG Yuping,CHU Tianjiao,et al.Expression of phosphatase of regenerating liver3 protein in breast invasive ductal carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(01):57-58.
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乳腺导管浸润癌组织中促肝细胞再生磷酸酶蛋白的表达* ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年01期
页码:
57-58
栏目:
论著
出版日期:
2010-01-30

文章信息/Info

Title:
Expression of phosphatase of regenerating liver3 protein in breast invasive ductal carcinoma tissue
作者:
曾宪旭△王玉萍楚天骄雷冬梅党秋红
郑州大学第三附属医院病理科郑州450052
Author(s):
ZENG XianxuWANG YupingCHU TianjiaoLEI DongmeiDANG Qiuhong
Department of Pathology,the Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
乳腺肿瘤导管浸润癌促肝细胞再生磷酸酶3
Keywords:
breast neoplasminvasive ductal carcinomaphosphatase of regenerating liver3
分类号:
R363.1
文献标志码:
A
摘要:
探讨乳腺导管浸润癌组织中促肝细胞再生磷酸酶(PRL3)的表达及其与临床病理特征之间的关系。方法:采用免疫组化SP法检测60例乳腺浸润性导管癌、6例乳腺正常组织、15例轻中度和20例重度不典型增生组织中PRL3的表达及其与乳腺浸润性导管癌临床病理特征之间的关系。结果:PRL3蛋白在乳腺正常组织、乳腺导管轻中度不典型增生、重度不典型增生和乳腺导管浸润癌组织中的阳性表达率分别为0、46.7%、80.0%和95.0%,4组间比较,差异有统计学意义(P=0.008);组间两两比较,差异均有统计学意义(P<0.01)。乳腺浸润性导管癌中PRL3蛋白与淋巴结转移和组织学分级有关(χ2=6.494,P=0.011和0.008)。结论:PRL3蛋白可能与乳腺浸润性导管癌的发生发展及转移有关。
Abstract:
To study the expression of PRL3 and the relationship with clinical pathological features in breast cancer progression.Methods:The expression of PRL3 was examined in 60 cases of breast invasive ductal carcinoma tissue and 6 cases of normal breast tissue,15 cases of mildmiddle atypical hyperplasia, and 20 cases of severe atypical hyperplasia breast tissue by immunohistochemical staining. The relationship between PRL3 expression and clinicopathological factors was analyzed.Results: The positive expression rates of PRL3 protein in normal breast,mildmiddle atypical hyperplasia,severe atypical hyperplasia and breast invasive carcinoma tissue were 0,46.7%,80.0%,and 95.0%,there were significant differences between them (P=0.008).The positive expression rate of PRL3 in invasive ductal carcinoma tissue was related with histological grade and lymphatic metastasis(χ2=6.494;P=0.011,0.008).Conclusion:PRL3 protein may be involved in the occurrence,development and metastasis of breast carcinoma.

参考文献/References:

[1]Bessette DC,Qiu D,Pallen CJ.PRL PTPs: mediators and markers of cancer progression[J].Cancer Metastasis Rev,2008,27(2):231
[2]Miskad UA,Semba S,Kato H, et al.Expression of PRL3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis[J].Pathobiolgy,2004,71(4):176
[3]Matter WF,Estridge T,Zhang C,et al.Role of PRL3:a human musclespecific tyrosine phosphatase,in angiotensinⅡsignaling[J].Biochem Biophys Res Commun,2001,283(5):1 061
[4]Radke I, Gotte M, Kersting C,et al. Expression and prognostic impact of the protein tyrosine phosphatases PRL1, PRL2, and PRL3 in breast cancer[J].Br J Cancer,2006,95(3):347
[5]Wang L, Peng L, Dong B,et al. Overexpression of phosphatase of regenerating liver3 in breast cancer: association with a poor clinical outcome[J].Ann Oncol,17(10):1 517
[6]Zeng Q,Si X,Horstmann H,et al.Prenylationdependent association of proteintyrosine phosphatases PRL1,2, and 3 with the plasma membrane and the early endosome[J].Biol Chem,2000,275(28):21 444
[7]Peng L,Ning J,Meng L,et al.The association of the expression level of protein tyrosine phosphatase PRL3 protein with liver metastasis and prognosis of patients with colorectal cancer[J].J Cancer Res Clin Oncol,2004,130(9):521

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备注/Memo

备注/Memo:
*河南省科技攻关基金资助项目072102310061 △女,1977年生,硕士,主治医师,研究方向:肿瘤分子病理学,Email:hawkshiyin1122@163.com
更新日期/Last Update: 2010-04-26