[1]张颖)),史惠蓉)#.卵巢上皮性肿瘤组织中人组织激肽释放酶15和CA125蛋白的表达*[J].郑州大学学报(医学版),2010,(01):62-64.
 ZHANG Ying),SHI Huirong).Expressions of human kallikrein15 and CA125 in epithelial ovarian tumor tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(01):62-64.
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卵巢上皮性肿瘤组织中人组织激肽释放酶15和CA125蛋白的表达*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年01期
页码:
62-64
栏目:
论著
出版日期:
2010-01-30

文章信息/Info

Title:
Expressions of human kallikrein15 and CA125 in epithelial ovarian tumor tissue
作者:
张颖1)2)史惠蓉1)#
1)郑州大学第一附属医院妇产科郑州4500522)郑州市中心医院妇产科郑州450052
Author(s):
ZHANG Ying12)SHI Huirong1)
1)Department of Obstetrics and Gynecology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500522)Department of Obstetrics and Gynecology,Zhengzhou Central Hospital,Zhengzhou 450052
关键词:
卵巢上皮性肿瘤组织激肽释放酶15CA125
Keywords:
epithelial ovarian neoplasmKLK15CA125
分类号:
R737.3
文献标志码:
A
摘要:
检测卵巢上皮性肿瘤组织中人组织激肽释放酶15(KLK15)和CA125蛋白的表达。方法:采用免疫组化SP法检测10例正常卵巢组织、18例卵巢良性肿瘤组织、16例卵巢交界性肿瘤组织和64例卵巢恶性肿瘤组织中KLK15与CA125蛋白的表达。结果:上述4种组织中KLK15蛋白的阳性表达率分别为10.0%、16.7%、62.5%和64.1%,4种组织相比,差异有统计学意义(χ2=20.432,P<0.001);4种组织中CA125蛋白的阳性表达率分别为0.0%、5.6%、37.5%和71.9%,4种组织相比,差异有统计学意义(χ2=37.448,P<0.001)。KLK15蛋白的表达与卵巢癌患者的临床分期、病理分级及淋巴结转移有关(χ2=3.90,P=0.048;χ2=4.84,P=0.028;χ2=5.49,P=0.019)。CA125蛋白的表达与卵巢癌患者的病理类型有关(χ2=37.49,P<0.001)。卵巢浆液性癌组织中KLK15与CA125蛋白的表达有关联(rP=0.334,P=0.033)。结论:KLK15蛋白对卵巢上皮性癌的诊断具有一定的价值,可能作为其预后判断的指标。KLK15与CA125蛋白联合检测可能有助于提高卵巢上皮性癌诊断的准确性。
Abstract:
To detect the expressions of human kallikrein 15(KLK15) and CA125 in the epithelial ovarian tumor tissue.Methods:Immunohistochemical SP method was used to detect the expressions of KLK15 and CA125 in 10 cases of normal ovary tissue,18 cases of epithelial ovarian benign tumor tissue, 16 cases of borderline ovarian tumor tissue, and 64 cases of epithelial ovarian carcinoma tissue.Results:The expressions of KLK15 in the above 4 kinds of tissue were 10.0%,16.7%,62.5%,and 64.1%,and there were significant differences(χ2=20.432,P<0.001);the expression of CA125 in the above 4 kinds of tissue were 0.0%,5.6%,37.5%, and 71.9%,and there were significant differences(χ2=37.448 ,P<0.001). The expression of KLK15 was related with the clinical stage,pathological grades and lymph node metastasis(χ2=3.90,P=0.048;χ2=4.84,P=0.028;χ2=5.49,P=0.019).The expression of CA125 was related with the pathological types of epithelial ovarian carcinoma(χ2=37.49,P<0.001).The expressions of KLK15 and CA125 were associated in the serous epithelial ovarian carcinoma tissue(rP=0.334,P=0.033).Conclusion: KLK15 protein is valuable in the diagnosis and prognosis of epithelial ovarian carcinoma. Combining detection of the 2 parameters may be helpful to the diagnosis of epithelial ovarian carcinoma.

参考文献/References:

[1]Southan C. A genomic perspective on human proteases as drug targets[J]. Drug Discov Today, 2001, 6(13):681
[2]史惠蓉,寇歆馨.卵巢上皮性肿瘤组织及患者血清CA125检测[J].郑州大学学报:医学版,2008,43(2):324
[3]Yousef GM, Scorilas A, Jung K,et al. Molecular cloning of the human kallikrein 15 gene (KLK15):upregulation in prostate cancer[J].J Biol Chem,2001,276(1):53
[4]Stephan C, Yousef GM, Scorilas A,et al. Quantitative analysis of kallikrein 15 gene expression in prostate tissue[J].J Urol,2003,169(1):361
[5]Juretzka MM,Barakat RR,Chi DS,et al. CA125 level as a predictor of progressionfree survival and overall survival in ovarian cancer patients with surgically defined disease status prior to the initiation of intraperitoneal consolidation therapy[J]. Gynecol Oncol,2006,104(1):176
[6]Yousef GM, Scorilas A, Magklara A,et al.The androgenregulated gene human kallikrein 15(KLK15) is an independent and favourable prognostic marker for breast cancer[J]. Cancer, 2002,87(11):1 294

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备注/Memo

备注/Memo:
*河南省自然科学基金资助项目611044700 #通讯作者,女,1956年生,博士,教授,主任医师,研究方向:妇科肿瘤,Email:huirongshi@yahoo.com.cn
更新日期/Last Update: 2010-04-26