[1]樊素珍△,苑中甫.宫颈癌组织中AnnexinA2和Ki67蛋白的表达[J].郑州大学学报(医学版),2010,(01):81-83.
 FAN Suzhen,YUAN Zhongfu.Expression of Annexin A2 and Ki67 in cervical cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(01):81-83.
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宫颈癌组织中AnnexinA2和Ki67蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年01期
页码:
81-83
栏目:
论著
出版日期:
2010-01-30

文章信息/Info

Title:
Expression of Annexin A2 and Ki67 in cervical cancer tissue
作者:
樊素珍△苑中甫
郑州大学第一附属医院妇产科郑州450052
Author(s):
FAN Suzhen YUAN Zhongfu
Department of Obstetrics and Gynecology,the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052
关键词:
宫颈癌宫颈上皮内瘤变AnnexinA2细胞核增殖抗原
Keywords:
cervical cancer cervical intraepithelial neoplasiaAnnexin A2 Ki67
分类号:
R737.33
文献标志码:
A
摘要:
探讨宫颈癌组织中AnnexinA2和细胞核增殖抗原(Ki67)蛋白的表达。方法:采用免疫组化SP法检测74例宫颈癌组织、24例宫颈上皮内瘤变(CIN)组织及15例正常宫颈上皮组织中AnnexinA2和Ki67蛋白的表达,并分析其与宫颈癌患者临床病理特征的关系。结果:①从正常宫颈组织→CIN组织→宫颈癌组织,AnnexinA2蛋白阳性表达率逐渐增高[(13.3%(2/15),37.5%(9/24)和71.6%(54/74)],差异有统计学意义(χ2=23.155,P<0.001);宫颈癌组织中其阳性表达率高于CIN组织和正常宫颈组织(P均<0.001),CIN组织与正常宫颈组织中其阳性表达率差异无统计学意义(P>0.05);AnnexinA2蛋白表达与宫颈癌患者的年龄(χ2=7.320,P=0.007)、组织类型(χ2=7.619,P=0.006)、病理分级(χ2=6.118,P=0.013)和淋巴结转移(P=0.015)有关。②从正常宫颈组织→CIN组织→宫颈癌组织,Ki67蛋白阳性表达率逐渐增高[26.7%(4/15),37.5%(9/24)和82.4%(61/74)],差异有统计学意义(χ2=23.041,P<0.001);宫颈癌组织中Ki67蛋白阳性表达表达率高于CIN组织和正常宫颈组织(P均<0.001),CIN组织与正常宫颈组织中其阳性表达率差异无统计学意义(P>0.05);Ki67蛋白表达与宫颈癌患者的年龄(χ2=6.830,P=0.008)、病理分级(χ2=3.972,P=0.046)和临床分期(P=0.036)有关。结论:AnnexinA2和Ki67可作为宫颈癌诊断的辅助指标,对评价宫颈组织的恶性程度及预后可能有一定的参考价值。
Abstract:
To explore the expression of Annexin A2 and Ki67 in cervical cancer.Methods:The expressions of Annexin A2 and Ki67 in 74 cases of cervical cancer, 24 cases of CIN (Ⅰ~Ⅲ), and 15 cases of normal cervical epithelium were examined by immunohistochemistry. Their relationship to clinicopathologic features of cervical cancer was analyzed.Results: ①The positive rates of Annexin A2 expression in normal cervical epithelium, CIN and cervical cancer were 13.3%(2/15),37.5%(9/24) and 71.6%(54/74),respectively (χ2=23.155,P<0.001).The positive rate of Annexin A2 expression in cervical cancer was higher than that in CIN and normal cervical epithelium(P<0.001), and no statistical significance was found between normal cervical epithelium and CIN.Annexin A2 expression was related with the ages of cervical cancer patients (χ2=7.320,P=0.007),histological substype (χ2=7.619, P=0.006), pathological grade (χ2=6.118, P=0.013) and pelvic lymph node metastasis status (P=0.015).②The positive rates of Ki67 expression in normal cervical epithelium, CIN and cervical cancer were 26.7%, 37.5%and 82.4%,respectively (χ2=23.041,P<0.001).The positive rate of Ki67 expression in cervical cancer was higher than that in CIN and normal cervical epithelium(P<0.001).Ki67 expression was related with the age of the cervical cancer patients (χ2=6.830, P=0.008), pathological grade (χ2=3.972, P=0.046) and clinical stage (P=0.036).Conclusion:Annexin A2 and Ki67 may serve as a potential marker for cervical cancer diagnosis. It possibly has certain reference value in evaluating malignant degree of cervix organization and prognosis.

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备注/Memo

备注/Memo:
△女,1975年生,硕士,主治医师,研究方向:宫颈癌的诊治,Email:fansuzhen211004@126.com
更新日期/Last Update: 2010-04-26