[1]张弓,朱长举,宋燕,等.原发性肝细胞癌组织中EphA2和E钙黏素蛋白的表达[J].郑州大学学报(医学版),2010,(01):93-96.
 ZHANG Gong,ZHU Changju,SONG Yan,et al.Expression of EphA2 and Ecadherin in hepatocellular carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(01):93-96.
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原发性肝细胞癌组织中EphA2和E钙黏素蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年01期
页码:
93-96
栏目:
论著
出版日期:
2010-01-30

文章信息/Info

Title:
Expression of EphA2 and Ecadherin in hepatocellular carcinoma tissue
作者:
张弓朱长举宋燕李捷翟文龙赵永福张水军#
郑州大学第一附属医院普通外科郑州450052
Author(s):
ZHANG GongZHU ChangjuSONG YanLI JieZHAI WenlongZHAO YongfuZHANG Shuijun
Department of General Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
EphA2E钙黏素肝细胞
Keywords:
EphA2 Ecadherin carcinoma hepatocellular
分类号:
R735.7
文献标志码:
A
摘要:
探讨EphA2和E钙黏素蛋白在原发性肝细胞癌组织中的表达及其意义。方法:采用免疫组化方法检测EphA2和E钙黏素蛋白在72例肝癌组织、40例癌旁肝组织和10例正常肝组织中的表达情况。结果:正常肝组织、癌旁肝组织和肝癌组织中EphA2蛋白的阳性表达率分别为50.0%(5/10)、57.5%(23/40)和77.8%(56/72)(H=16.235,P<0.001),E钙黏素蛋白的阳性表达率分别为80.0%(8/10)、65.0%(26/40)和40.3%(29/72)(H=9.033,P=0.011);EphA2的过表达与肝癌患者的卫星灶、淋巴结转移及癌栓有关(χ2分别为7.160、3.952和4.879,P均<0.05),E钙黏素蛋白的过表达与淋巴结转移和卫星灶有关(χ2分别为4.500和6.583,P均<0.05)。肝癌组织中EphA2和E钙黏素蛋白的表达有关联性(rP=0.280,P=0.032)。结论:EphA2和E钙黏素联合作用,可能在肝癌的侵袭和转移中发挥重要作用。
Abstract:
To investigate the expression and clinical significance of EphA2 and Ecadherin in hepatocellular carcinoma(HCC) tissue.Methods:The expressions of EphA2 and Ecadherin protein were detected by immunohistochemistry technique in 72 cases of HCC tissue, 40 cases of paracancerous tissue and 10 cases of normal liver tissue.Results: From normal tissue to paracancerous tissue to HCC, the positive rates of EphA2 protein were 50.0%(5/10), 57.5%(23/40), and 77.8%(56/72), respectively(H=16.235,P<0.001). But from normal tissue to paracancerous tissue to HCC, the positive rates of Ecadherin protein were 80.0%(8/10), 65.0%(26/40), and 40.3%(29/72), respectively(H=9.033,P=0.011). The expressions of EphA2 and Ecadherin protein were related with satellite focus and lymph node metastasis(EphA2:χ2 was 7.160 and 3.952,P<0.05;Ecadherin:χ2 was 6.583 and 4.500,P<0.05).The expression of EphA2 was related with that of Ecadherin(rP=0.280,P=0.032) in HCC.Conclusion: The expression of EphA2 and Ecadherin may play an important role in the progression and metastasis of HCC.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1958年生,博士,教授,研究方向:肝胆胰外科与消化器官移植,Email:zhangshuijun@zzu.edu.cn
更新日期/Last Update: 2010-04-26