[1]王彦平),代丽萍),吴晓冰),等.细胞色素P4501A1 Ile/Val位点基因多态性与食管癌关系的meta 分析*[J].郑州大学学报(医学版),2010,(02):186-188.
 WANG Yanping),DAI Liping),WU Xiaobing),et al.Metaanalysis of cytochrome P4501A1 Ile/Val gene polymorphism with esophageal carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):186-188.
点击复制

细胞色素P4501A1 Ile/Val位点基因多态性与食管癌关系的meta 分析*()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年02期
页码:
186-188
栏目:
食管癌研究
出版日期:
2010-03-30

文章信息/Info

Title:
Metaanalysis of cytochrome P4501A1 Ile/Val gene polymorphism with esophageal carcinoma
作者:
王彦平1)代丽萍2)吴晓冰2)王凯娟2)吕全军3)#
1)河南农业职业学院食品科学系郑州4514502)郑州大学公共卫生学院流行病学教研室郑州4500013)郑州大学公共卫生学院营养与食品卫生学教研室郑州450001
Author(s):
WANG Yanping1) DAI Liping2) WU Xiaobing2)WANG Kaijuan2)LV Quanjun3)
1)Department of Food Science, Henan Vocational College of Agriculture, Zhengzhou 4514502)Department of Epidemiology,College of Public Health, Zhengzhou University, Zhengzhou 4500013)Department of Food and Nutrition Hygiene,College of Public Health, Zhengzhou University, Zhengzhou 450001
关键词:
食管肿瘤细胞色素P4501A1Ile/Val位点基因多态性meta分析
Keywords:
esophageal neoplasmcarcinomacytochrome P4501A1 Ile/Val gene polymorphism metaanalysis
分类号:
R735.1
文献标志码:
A
摘要:
探讨细胞色素P4501A1(CYP1A1)Ile/Val位点基因多态性与食管癌发生的关系。方法:对国内外1997至2008年采用病例对照方法研究CYP1A1Ile/Val基因多态性与食管癌发生关系的14篇文献(累计食管癌病例1158例、对照2154例)进行meta分析,应用显性模型(突变基因型Ile/Val+Val/Val与野生基因型Ile/Ile比较)先进行综合定量分析,再按病理类型(鳞癌/腺癌)分亚组进行分析。结果:综合分析显示携带CYP1A1突变基因型(Ile/Val+Val/Val)的个体发生食管癌的危险性是野生型的1.39倍(95%CI1.07~1.80);亚组分析显示突变基因型与食管鳞癌发生的易感性有关但与食管腺癌无关,OR值分别为1.43(95%CI1.07~1.91)和1.20(95%CI0.62~2.30)。结论:CYP1A1Ile/Val位点突变基因型可增加食管鳞癌发生的危险性,但与食管腺癌无关。
Abstract:
To examine the relationship between the cytochrome P4501A1(CYP1A1) Ile/Val gene polymorphism and occurrence of esophageal carcinoma.Methods:Data from 14 literatures about casecontrol studies on association of CYP1A1 Ile/Val gene polymorphism with esophageal carcinoma risk were analyzed using metaanalysis by dominant model [(Ile/Val+Val/Val)/(Ile/Ile)].A total of 1 158 esophageal carcinoma cases and 2 154 controls were included in the analysis.Results:The association between CYP1A1 Ile/Val and esophageal carcinoma had statistical significance with OR of 1.39(95% CI 1.07~1.80). In subgroupanalysis the ORs of CYP1A1 Ile/Val and esophageal squamous cell carcinoma (ESCC),esophageal adenocarcinoma (EAC) were 1.43(95% CI 1.07~1.91) and 1.20(95% CI 0.62~2.30),respectively.Conclusion: CYP1A1 Ile/Val variant genotype may increase the risk of ESCC, but has no association with EAC.

参考文献/References:

[1]Tan W, Song N, Wang GQ, et al. Impact of genetic polymorphisms in cytochrome p450 2E1 and glutathione Stransferases M1,T1,and P1 on susceptibility to esophageal cancer among highrisk individuals in China[J]. Cancer Epidemiol Biomarkers Prev,2000,9(6):551
[2]Xing D, Tan W, Lin D. Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population[J].Oncol Rep, 2003,10(5):1 615
[3]Casson AG, Zheng Z, Chiasson D,et al. Associations between genetic polymorphisms of Phase Ⅰ and Ⅱ metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma[J].Cancer Detect Prev,2003(27):139
[4]Morita S, Yano M, Shiozaki H, et al. CYP1A1,CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamouscell carcinoma of the esophagus[J]. Int J Cancer,1997,71(2):192
[5]Wang LD, Zheng S, Liu B, et al. CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma:study of population from a highincidence area in north China[J]. World J Gastroenterol, 2003,9(7):1 394
[6]Wu MT, Lee JM, Wu DC, et al. Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamouscell carcinoma in Taiwan[J]. Br J Cancer, 2002,87(5):529
[7]Wideroff L,Vaughan TL,Farin FM,et al.GST,NAT1,CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas[J]. Cancer Detect Prev,2007,31(3):233
[8]Abbas A,Delvinquiere K, Lechevrel M, et al. GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population:different pattern of squamous cell carcinoma and adenocarcinoma[J]. World J Gastroenterol, 2004,10(23):3 389
[9]Wang AH, Sun CS, Li LS, et al. Genetic susceptibility and environmental factors of esophageal cancer in Xi’an[J]. World J Gastroenterol, 2004,10(7):940
[10]杨靖,杨瑞森,李会庆,等.细胞色素P1A1氧化酶基因型与食管癌易感性的研究[J].中国肿瘤临床与康复,2004,11(1):9
[11]韩艳波,冯向先,李佩珍,等.CYP1A1、GSTM1基因多态性与食管癌遗传易感性[J].中国公共卫生,2005,21(1):3
[12]邵根泽,苏艳蓉,黄革,等. CYP1A1、GSTM1基因多态性与食管癌遗传易感性的关系[J].中华流行病学杂志,2000,21(6):420

[13]张宏艳,闫明晓,孙长生,等.西安地区食管癌的遗传流行病学[J].第四军医大学学报,1999, 20(10):841

[14]Hori H, Kawano T, Endo M, et al. Genetic polymorphisms of tobacco and alcoholrelated metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility[J]. J Clin Gastroenterol,1997,25(4):568
[15]van Lieshout EM, Roelofs HM, Dekker S, et al. Polymorphic expression of the glutathione Stransferase P1 gene and its susceptibility to Barrett’s esophagus and esophageal carcinoma[J]. Cancer Res,1999,59(3):586
[16]Nimura Y, Yokoyama S, Fujimori M, et al. Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking[J]. Cancer,1997,80(5):852
[17]Yang CX, Matsuo K, Wang ZM, et al. Phase Ⅰ/Ⅱ enzyme gene polymorphisms and esophageal cancer risk:a metaanalysis of the literature[J]. World J Gastroenterol, 2005,11(17):2 531

相似文献/References:

[1]庞霞,郑湘予,李晟磊,等.食管鳞癌组织中半乳糖凝集素3和Bcl2蛋白的表达*[J].郑州大学学报(医学版),2010,(01):8.
 PANG Xia,ZHENG Xiangyu,LI Shenglei,et al.Expression of Galectin3 and Bcl2 protein in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):8.
[2]崔玲玲),李春阳),王旗),等.食管鳞癌组织中EphrinB2、半胱氨酸蛋白酶8蛋白和mRNA的表达*[J].郑州大学学报(医学版),2010,(01):21.
 CUI Lingling),LI Chunyang),WANG Qi),et al.Expression of EphrinB2 and Caspase8 protein and mRNA in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):21.
[3]张弓,朱长举,宋燕,等.原发性肝细胞癌组织中EphA2和E钙黏素蛋白的表达[J].郑州大学学报(医学版),2010,(01):93.
 ZHANG Gong,ZHU Changju,SONG Yan,et al.Expression of EphA2 and Ecadherin in hepatocellular carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):93.
[4]吴欣爱),王筱璨),樊青霞),等.食管鳞状细胞癌组织中乏氧诱导因子1α蛋白和mRNA的表达[J].郑州大学学报(医学版),2010,(02):183.
 WU Xinai),WANG Xiaocan),FAN Qingxia),et al.Expression of HIF1α protein and mRNA in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):183.
[5]刘欣欣,赵江沙,印宏坤,等.食管鳞状细胞癌组织中表皮调节素、双调蛋白及表皮生长因子受体mRNA的表达[J].郑州大学学报(医学版),2010,(02):189.
 LIU Xinxin,ZHAO Jiangsha,YIN Hongkun,et al.Expression of epiregulin,amphiregulin,and epidermal growth factor receptor mRNA in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):189.
[6]何卫华,史惠蓉#.卵巢上皮性癌组织中黏着斑激酶和肝癌缺失基因1 mRNA的表达*[J].郑州大学学报(医学版),2010,(02):209.
 HE Weihua,SHI Huirong.Expression of focal adhesion kinase and deleted in liver cancer 1 mRNA in epithelial ovarian cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):209.
[7]马洪涛△,史艳平,封全灵.卵巢上皮性癌组织中磷酸化信号转导及转录活化因子3和Ki67蛋白的表达[J].郑州大学学报(医学版),2010,(02):246.
 MA Hongtao,SHI Yanping,FENG Quanling.Expression of psignal transducers and activators of transcription3 and Ki67 in epithelial ovarian carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):246.
[8]陈妍琼),赵志华),张蕾)#,等.食管鳞状细胞癌组织中KiSS1蛋白和微血管密度的检测*[J].郑州大学学报(医学版),2009,(06):1127.
 CHEN Yanqiong),ZHAO Zhihua),ZHANG Lei),et al.Expressions of KiSS1 protein and detection of MVD in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):1127.
[9]陈玉,亚国伟,张威,等.雷帕霉素靶蛋白RNA干扰联合雷帕霉素对人食管癌移植瘤生长和移植瘤组织中雷帕霉素蛋白基因表达的影响*[J].郑州大学学报(医学版),2009,(06):1135.
 CHEN Yu,YA Guowei,ZHANG Wei,et al.Effects of RNAi combined with rapamycin on expression of mTOR gene in tumor tissue of nude mice transplanted with human esophageal cancer cells[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):1135.
[10]史祖宣,李克,樊青霞#.食管鳞状细胞癌组织中神经性钙黏附蛋白和mRNA的表达*[J].郑州大学学报(医学版),2009,(06):1138.
 SHI Zuxuan,LI Ke,FAN Qingxia.Expression of Ncadherin protein and mRNA in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):1138.
[11]张威,陈玉,亚国伟,等.RNA干扰对EC9706细胞mTOR表达及细胞生长与凋亡的影响*[J].郑州大学学报(医学版),2010,(01):11.
 ZHANG Wei,CHEN Yu,YA Guowei,et al.Effect of mTOR siRNA on the expression of mTOR gene,growth and apoptosis of human esophageal carcinoma EC9706 cells[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):11.
[12]申秋),王立东)﹟,常扶保),等.食管癌和贲门癌手术切除标本离体前后及固定后的收缩变化*[J].郑州大学学报(医学版),2009,(01):37.
 SHEN Qiu),WANG Lidong),CHANG Fubao),et al.Effects of specimens shrinkage by surgical resection and fixation on esophageal and gastric cardia cancers[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):37.
[13]刘桂举,梅家转,肖鹏,等.化疗联合细胞因子诱导的杀伤细胞治疗晚期食管癌的疗效[J].郑州大学学报(医学版),2011,(02):169.
 LIU Guiju,MEI Jiazhuan,XIAO Peng,et al.Efficacy of chemotherapy combined with cytokineinduced killer cells in treatment of advanced esophageal carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):169.

备注/Memo

备注/Memo:
#通讯作者,男,1962年生,博士,教授,研究方向:营养相关疾病,Email:lqjnutr@zzu.edu.cn*国家自然科学基金资助项目30872181;教育部“211工程”基金资助项目;河南省科技攻关计划基金资助项目031161200
更新日期/Last Update: 2010-04-29