[1]冯静)△,陈小兵),赵明耀),等.合并肝转移的结直肠癌组织中VEGF和Survivin蛋白的表达*[J].郑州大学学报(医学版),2010,(02):207-208.
 FENG Jing),CHEN Xiaobing),ZHAO Mingyao),et al.Expression of VEGF and Survivin protein in colorectal carcinoma tissue with liver metastasis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):207-208.
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合并肝转移的结直肠癌组织中VEGF和Survivin蛋白的表达*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年02期
页码:
207-208
栏目:
论著
出版日期:
2010-03-30

文章信息/Info

Title:
Expression of VEGF and Survivin protein in colorectal carcinoma tissue with liver metastasis
作者:
冯静1)陈小兵2)赵明耀1)董子明1)罗素霞2)曹新广2)韩广森2)
1)郑州大学基础医学院病理生理学教研室郑州4500012)河南省肿瘤医院内科郑州450008
Author(s):
FENG Jing1)CHEN Xiaobing2)ZHAO Mingyao1)DONG Ziming1)LUO Suxia2)CAO Xinguang2)HAN Guangsen2)
1)Department of Pathophysiology, College of Basic Medical Sciences, Zhengzhou University,Zhengzhou 4500012)Department of Internal Medicine, Henan Tumor Hospital, Zhengzhou 450008
关键词:
VEGFSurvivin结直肠癌肝转移
Keywords:
VEGFSurvivincolorectal carcinomaliver metastasis
分类号:
R735.3
文献标志码:
A
摘要:
探讨合并肝转移的结直肠癌组织中VEGF和Survivin蛋白的表达情况。方法:采用免疫组织化学法检测80例结直肠癌(腺癌50例,有肝转移者24例,无肝转移者26例;黏液腺癌30例,有肝转移者14例,无肝转移者16例)组织中VEGF与Survivin蛋白的表达。结果:结直肠癌腺癌和黏液腺癌组织中有肝转移组VEGF和Survivin的阳性表达率(VEGF:79.2%和85.7%;Survivin:83.3%和92.9%)分别高于无肝转移组(VEGF:34.6%和25.0%;Survivin:38.5%和31.3%,χ2=10.053,11.059,10.470和11.808,P<0.05)。结直肠癌组织中VEGF与Survivin的阳性表达率呈正关联(rP=0.323,P<0.001)。结论:VEGF和Survivin的表达与结直肠癌肝转移的发生有密切关系,联合检测2者可用于判断结直肠癌的恶性程度和预后。
Abstract:
To detect the expressions of vascular endothelial growth factor(VEGF) and Survivin in colorectal carcinoma tissue with liver metastasis.Methods:The expressions of VEGF and Survivin in 80 cases of colorectal carcinoma (50 cases of adenocarcinoma,among which,24 were complicated with liver metastasis;30 cases of mucinous adenocarcinoma,among which,14 were complicated with liver metastasis) tissue were detected using immunohistochemistry.Results: The positive expression rates of VEGF and Survivin in adenocarcinoma and mucinous adenocarcinoma tissue with liver metastasis(VEGF:79.2% and 85.7%;Survivin:83.3% and 92.9%) were higher than those without liver metastasis(VEGF:34.6% and 25.0%;Survivin:38.5% and 31.3%)(χ2=10.053,11.059,10.470 and 11.808,P<0.01). The expressions of VEGF and Survivin in colorectal carcinoma tissue were positively correlated(rP=0.323,P<0.001).Conclusion: The expressions of VEGF and Survivin might be closely related with colorectal liver metastasis. The expressions of VEGF and Survivin could reflect the malignant degree of colorectal carcinoma and be used as the prognostic predictors.

参考文献/References:

[1]张苏展,胡跃.我国结直肠癌肝转移诊治现状[J].实用肿瘤杂志,2007,22(3):194
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[5]Kawasaki H,Toyoda M,Shinohara H,et al.Expression of survivin correlates with apoptosis, proliferation,and angiogenesis during human colorectal tumorigenesis[J]. Cancer, 2001, 91(11):2 026

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备注/Memo

备注/Memo:
*河南省医学科技创新人才工程基金资助项目200616△女,1982年生,硕士研究生,研究方向:肿瘤病理生理学,Email:fengjingann@163.com
更新日期/Last Update: 2010-04-29